结核性胸膜炎患者胸腔积液中TLR2、TLR4水平变化及临床意义

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Abstract Objective To investigate the changes and clinical significance of Toll-like receptor 2 (TLR2) and Toll-like receptor 4 (TLR4) levels in pleural effusion of patients with tuberculous pleurisy. Methods From January 2016 to December 2018, 102 patients with tuberculous pleurisy who were admitted to the Third People′s Hospital of Shenzhen ("our hospital" for short) were selected（group A）, and 80 patients with malignant pleural effusion (group B) and 62 patients with bacterial pneumonia(group C). The enzyme-linked immunosorbent assay was used to detect all the TLR2 and TLR4, tumor necrosis factor alpha (TNF-α), monocyte chemotactic protein-2 (MCP-2), matrix metalloproteinase 1 (MMP-1) levels, Pearson correlation coefficient method was used to analyze correlation of TLR2, TLR4 and TNF-α, MCP-2, MMP 1; the receiver-operating characteristic curve (ROC) analysis was adopted to assess the diagnostic value of TLR2 and TLR4. Results The levels of TLR2, TNF-α, MCP-2 and MMP-1 in group A were higher than those in group B and group C (P ＜ 0.05). Pearson correlation coefficient analysis showed that TLR2 was positively correlated with TNF-α, MCP-2 and MMP-1 in tuberculous pleurisy (P ＜ 0.05), while TLR4 was not correlated with TNF-α, MCP-2 and MMP-1 (P ＞ 0.05). TLR2 was positively correlated with TLR4 in patients with tuberculous pleurisy (P ＜ 0.05). The area under the curve of TLR2 in diagnosis of tuberculous pleurisy was 0.724, which was significantly higher than that under the curve of TLR4 (P ＜ 0.05). Conclusion TLR2 levels in tuberculous pleurisy patients show a significant upward trend, and are significantly positively correlated with TNF-α, MCP-2 and MMP-1 in pleural effusion, which may be involved in the occurrence and development of tuberculous pleurisy and have a better diagnostic value for tuberculous pleurisy.

Key words： Tuberculous pleurisy Pleural effusion TLR2 TLR4 Clinical significance

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	YE Taosheng ZHANG Jiaohong ZHANG Peize ZENG Xuan XU Yuxiang LI Min

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YE Taosheng ZHANG Jiaohong ZHANG Peize ZENG Xuan XU Yuxiang LI Min. Changes and clinical significance of TLR2 and TLR4 levels in pleural effusion of patients with tuberculous pleurisy[J]. 中国医药导报, 2019, 16(17): 117-120.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I17/117

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