入院前FRAIL评分和入室后SOFA评分与脓毒性休克患者预后的关系

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Abstract Objective To investigate the relationship between the pre-admission FRAIL score and the first 24-hour sequential organ failure score (SOFA) after admission of patients with septic shock and their prognosis, so as to guide clinicians to choose appropriate treatment time and timely treatment. Methods From January 2016 to February 2018, 113 patients with septic shock who were hospitalized in the ICU of the Fuxing Hospital Affiliated to Capital Medical University, were enrolled. The 28-day entry was used as the end point of observation endpoint, and those who continued to be treated or cured or discharged from ICU within 28 days as survival group observation, and those who died within 28 days as death group. The general data, FRAIL score, acute physiology and chronic health evaluation score (APACHEⅡ), arterial blood lactate (LAC) and procalcitonin (PCT) levels were compared between the two groups. Logistic regression model was used to analyze the prognostic factors of patients. The mortality risk of septic shock was predicted by SOFA, FRAIL alone and combined with SOFA and FRAIL, and the ROC curve was drawn to observe the predictive value of FRAIL scores and SOFA scores for prognosis in patients with septic shock. Results At the end of 28 days, 53 patients survived and 60 died. There were significant differences in PCT, FRAIL and SOFA between the two groups (P < 0.05). The above three indicators were used as independent variables, survival and death were used as dependent variables, Logistic regression analysis was performed, and the early warning equation of septic shock death was used. It is logit (P) =-16.045+1.608×FRAIL+1.235×SOFA. The combination of SOFA and FRAIL had the greatest predictive value for predicting septic shock death (AUC=0.928, P < 0.01). Conclusion There are many factors influencing the prognosis of patients with sepsis in ICU. Combined FRAIL score and SOFA score are simple and effective indicators for predicting death in patients with sepsis in ICU.

Key words： Septic shock FRAIL Sequential organ failure score Prognosis

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	YIN Yanyan1 DONG Bingsheng2 JIANG Li2

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YIN Yanyan1 DONG Bingsheng2 JIANG Li2. Relationship between the pre-admission FRAIL score and SOFA score after admission of patients with septic shock and their prognosis[J]. 中国医药导报, 2019, 16(17): 105-108,120.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I17/105

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