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| Effect of angiogenesis inhibitor on soft tissue sarcoma：a Meta-analysis |
| LIN Feifan1 LI Min2 SHI Xuejun1▲ |
1.Department of Medical Oncology, Affiliated Yongchuan Hospital of Chongqing Medical University, Chongqing 402160, China;
2.Department of Anesthesiology, Affiliated Yongchuan Hospital of Chongqing Medical University, Chongqing 402160, China |
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Abstract Objective To evaluate the clinical effect of angiogenesis inhibitors on the advanced soft tissue sarcoma by Meta-analysis. Methods The database of PubMed, The Cochrane Library, EMbase and CNKI were searched by computer. After selecting the documents and extracting the data according to the inclusion and exclusion criteria, the randomized controlled clinical trials of angiogenesis inhibitors in the treatment of advanced soft tissue sarcoma was selected, and RevMan 5.3 was selected to work out the Meta-analysis. The search time was from begin of database to January 2019. Results 8 RCTs including 991 cases of patients were identified. Meta analysis showed that angiogenesis inhibitors can effectively improve the rate of progress in half a year [OR = 2.44, 95%CI (1.11, 5.38), P = 0.03], objective reaction rate [OR = 1.89, 95%CI (1.15, 3.10), P = 0.01] and disease control [OR = 3.33, 95%CI(2.46, 4.53), P < 0.00 001], there was no significant difference between angiogenesis inhibitors and control group in the half-year survival rate [OR = 0.94, 95%CI(0.66, 1.32), P = 0.71]. Conclusion Angiogenesis inhibitors are effective in the treatment of advanced soft tissue sarcoma, they can effectively improve the rate of progress in half a year, objective reaction rate and disease control and they are valuable in clinical treatment.
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