全脑放疗联合榄香烯注射治疗多发脑转移瘤的临床观察

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Abstract Objective To explore the efficacy and side effects of Elemene Injection combined with whole brain radiotherapy in the treatment of multiple brain metastases. Methods A total of 56 patients with brain metastases treated by whole brain radiotherapy in BenQ Medical Center from April 2014 to April 2017 were collected. The changes of symptoms during hospitalization and the data of brain MRI after radiotherapy were collected. According to whether elemene was used or not, the patients were divided into elemene group and radiotherapy group. The changes of tumor size, symptom improvement and toxicity were compared between the two groups. Results The objective response rate between the elemene group (47.37%) and radiotherapy group (44.44%) had no signficant difference (P ＞ 0.05). Compared with radiotherapy group, elemene group was better in controlling the symptoms of dizziness and headache, vomiting and fatigue (P ＜ 0.05), without increasing the control rate of neurological symptoms and the conditions of acute radiotoxicity. When it came to the long-term radiotherapy response (after 6 months of radiotherapy), the incidence rate of memory loss in the elemene group was 21.74%, which was significantly lower than 63.64% in the radiotherapy group (P ＜ 0.05). Conclusion Whole brain radiotherapy combined with Elemene Injection can increase the effect of radiotherapy and the rate of symptom control. But it can not increase the objective remission rate. Compared with radiotherapy alone, it dosen't increase acute radiotoxicity and can reduce the late toxicity to some extent. Elemene in combination with whole brain radiotherapy may be used in patients with brain metastases who are not suitable for chemotherapy or who are resistant to chemotherapy.

Key words： Whole brain radiotherapy Elemene Multiple brain metastases Radiosensitization

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	HU Daoqing1 LI Xiaodong2

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HU Daoqing1 LI Xiaodong2. Clinical observation of combined therapy of whole brain radiotherapy and Elemene Injection in the treatment of multiple brain metastases[J]. 中国医药导报, 2019, 16(17): 80-83,91.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I17/80

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