学龄前儿童骨密度与血清25-（OH）D水平的相关性

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Abstract Objective To investigate the bone mineral density (BMD) in preschool children and its relationship with serum 25-hydroxyvitamin D [25-(OH)D]. Methods From March 2017 to March 2018, 629 preschool children aged 0-7 who underwent BMD examination in the Outpatient Department of Child Health Care of Sanya City Womenfolk and Infant Health Care Hospital were collected as subjects. BMD was measured by quantitative ultrasound, according to BMD level, the subjects were divided into normal BMD group (n = 492) and abnormal BMD group (n = 137). The influencing factor of BMD of preschool children was analyzed by multivariate Logistic regression analysis. The level of 25-(OH) was determined by ELISA, the BMD of children with different 25-(OH)D level was compared. Pearson product moment correlation analysis was used to analyze the correlation between BMD and serum 25-(OH)D in preschool children. Results The abnormal rate of BMD in preschool children was 21.78%, which in children aged 5-7 was higher than that in others, followed by children aged 1. The abnormal rate of BMD in girls, children aged 1-year-old and 5-7-year-old was higher than that in boys and children aged 2-4-year-old (P < 0.05). The abnormal rate of BMD in preschool children with activity time ≤3 h/week, sleeping time ≤8 h/d, sunshine time ≤7 h/d was higher than that of children whose activity time >3 h/week, sleeping time >8 h/d and sunshine time >7 h/d (P < 0.05). The abnormal rate of BMD in preschool children with picky diet, vitamin D intake ≤400 U/d, dairy intake ≤150 mL/d, bean products intake ≤4 times/week, fruit intake ≤5 times/week was higher than those of children without picky diet, vitamin D intake > 400 U/d, dairy intake >150 mL/d, bean products intake > 4 times/week, fruit intake > 5 times/week (P < 0.05). Compared with 2-year-old children, 1-year-old and 5-7-year-old was independent risk factors for abnormal BMD (OR = 1.113, 1.373, 1.433, 1.479, P < 0.05). Activity time, sleeping time, sunshine time, picky diet, vitamin D intake, dairy intake, bean products intake, fruit intake was the influencing factor of abnormal BMD in preschool children (OR = 1.377, 1.654, 1.642, 1.525, 1.788, 1.598, 1.384, 1.443, P < 0.05). With the decrease of 25-(OH)D level, SOS value increased gradually, Z value decreased gradually, and abnormal rate of BMD increased gradually (P < 0.05).There was a negative correlation between SOS and serum 25-(OH) D in preschool children (r = -0.729, P < 0.05), and a positive correlation between Z value and serum 25-(OH) D (r = 0.761, P < 0.05). Conclusion The abnormal rate of BMD in preschool children is higher, especially in children aged 1 and 5-7 years. Vitamin D and calcium should be supplemented reasonably for children at high risk of BMD, outdoor activities should be strengthened, and balanced diet should be paid attention to.

Key words： Preschool children Bone mineral density 25-hydroxyvitamin D Correlation

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	XING Cunqiao CHEN Haiqiong CENG Guangping

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XING Cunqiao CHEN Haiqiong CENG Guangping. The correlation between bone mineral density and serum 25-（OH）D level in preschool children[J]. 中国医药导报, 2019, 16(17): 63-67.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I17/63

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