DC-CIK细胞免疫治疗联合化疗治疗晚期卵巢癌的效果及对免疫功能的影响

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Abstract Objective To explore the effect of dendritic cell-cytokine induced killer cell (DC-CIK) immunotherapy combined with chemotherapy for patients with advanced ovarian cancer and its influence on immune function. Methods A total of 70 patients with advanced ovarian cancer in Xindu District People′s Hospital of Chengdu from January 2015 to December 2017 was divided into two groups according to the random number table method. The control group (n = 35) was treated with Paclitaxel combined with Cisplatin, and the observation group (n = 35) was treated with DC-CIK immunotherapy on the base of control group. Continuous treatment for three courses, and follow up for 6 months, the clinical efficacy between two groups was compared. The comparisons of immune function indexes such as CD3+, CD4+, CD8+, CD19, CD16+CD56+ between two groups before and after treatment was conducted. The adverse reactions during the course of treatment were recorded and compared between the two groups. Results Six months after followed up, the disease control rate and objective remission rate in the observation group were higher than those in the control group, the differences were statistically significant (P < 0.05). The liver dysfunction and bone marrow suppression in the observation group were respectively lower than those in the control group, and the total incidence of adverse reactions in the observation group was lower than that in the control group, the differences were statistically significant (P < 0.05). After treatment, the levels of CD3+, CD4+, CD19 and CD16+CD56+ in two groups were significantly higher than those before treatment, and CD8+ level was lower than that before treatment, and the levels of CD3+, CD4+, CD19 and CD16+CD56+ in the observation group were higher than those in the control group, while the CD8+ level in the observation group was lower than that in the control group, the differences were statistically significant (P < 0.05). Conclusion DC-CIK cell immunotherapy combined with chemotherapy can significantly improve the clinical efficacy and enhance immune function, which has fewer adverse reactions and worthy of clinical promotion.

Key words： DC-CIK cellular immunotherapy Chemotherapy Advanced ovarian cancer Clinical efficacy Immune function

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	PENG Juan1 CUI Manman2

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PENG Juan1 CUI Manman2. Effect of DC-CIK cellular immunotherapy combined with chemotherapy on clinical efficacy and immune function in patients with advanced ovarian cancer[J]. 中国医药导报, 2019, 16(17): 59-62.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I17/59

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