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Clinical effect of Tomoxetine Hydrochloride for children with ADHD complicated by transient tic disorder |
JIN Lan WANG Yi ZHANG Wenjing TIAN Le▲ |
Department of Neurology, Inner Mongolia Mental Health Center, Inner Mongolia Autonomous Region, Huhhot 010020, China |
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Abstract Objective To observe the clinical treatment of children with attention deficit hyperactivity disorder (ADHD) complicated by transient tic disorder treated by Tomoxetine Hydrochloride. Methods The clinical data of 128 children with ADHD complicated by transient tic disorder who had received treatment in the Outpatient Service of Inner Mongolia Mental Health Center from July 2016 to July 2018 were enrolled in the study, and they were divided into two groups according to the different treatment options, with 64 cases in each group. The control group was treated with Methylphenidate Hydrochloride, whereas the observation group was treated with Tomoxetine Hydrochloride. The efficacy, cognitive function, adverse reactions and other indicators were compared between the two groups. Results The total effective rate of treatment in the observation group was higher than that in the control group after 2 months of treatment (P < 0.05). There were no statistical differences in the Cormer factor scores between the two groups before treatment (P > 0.05), however, these scores were lower than before treatment in both groups (P < 0.05). The scores of learning, behavior, anxiety and other factors in the observation group were lower than those in the control group (P < 0.05). Before treatment, there was no statistical difference between the two groups in the scores of exercise twitch and vocal twitch (P > 0.05), these scores were reduced in both groups after treatment (P < 0.05), and these scores in the observation group were lower than those in the control group (P < 0.05). There were no statistical differences in the scores of cognitive function between the two groups before treatment (P > 0.05); after treatment, however, the scores were increased than before treatment in both groups (P < 0.05). The counting, coding, digital breadth, and C factor in the observation group were higher than those in the control group (P < 0.05). The incidence of adverse reactions in the observation group was lower than that in the control group (P < 0.05). Conclusion For children with ADHD complicated by transient tic disorder, Tomoxetine Hydrochloride is safe, effective and with significant curative effect, which can help improve ADHD, reduce tic disorder, correct cognitive function and enhance clinical efficacy, yet incurring fewer adverse reactions.
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