Abstract Objective To investigate the related factors influencing the curative effect in secondary hemichorea patients, and to provide early effective intervention. Methods Clinical data of 38 patients with secondary hemichorea diagnosed in Beijing Luhe Hospital, Capital Medical University from November 2012 to November 2017 was retrospectively analyzed. Logistic regression analysis was used to explore the relevant factors affecting the efficacy of secondary hemichorea. Results Among the 38 patients, 23 (60.5%) were caused by acute cerebrovascular disease, 6 patients (15.8%) by non-ketotic hyperglycemia and 9 patients (23.7%) by other causes. Following up showed that, 26 patients (68.4%) in the group with satisfactory self-efficacy and 12 patients (31.6%) with unsatisfactory efficacy, there were statistically significant difference in age, history of stroke, time from onset to first diagnosis and treatment, and location of lesions between the two groups (P < 0.05). Logistic regression analysis showed that stroke history (OR = 0.961, 95%CI: 1.423-61.658, P < 0.05) and lesion location (OR = 1.0253, 95%CI: 2.087-283.919, P < 0.05) were risk factors for poor outcome in patients with secondary hemichorea. Conclusion Acute cerebrovascular disease is the main etiology of secondary hemichorea, followed by hyperglycemia. Advanced age, stroke history, onset to first diagnosis time and location of lesions, respectively affects short-term prognosis of patients. Previous stroke history and non-basal ganglia or basal ganglia combined with other multi-site lesions are high risk factors for poor efficacy of secondary hemichorea, which should be paid high attention.
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