喹硫平联合颅磁刺激治疗老年痴呆精神行为症状的临床效果

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Abstract Objective To study the clinical effect of Quetiapine combined with transcranial magnetic stimulation in the treatment of mental and behavioral symptoms of senile dementia. Methods From October 2012 to June 2018, 100 patients of senile dementia with different degrees of mental and behavioral symptoms who were treated in Qingdao Mental Health Center were selected. They were divided into control group (50 cases) and study group (50 cases) by random number table method. Patients in both groups were given conventional treatment, the control group was treated with Quetiapine, and the study group was treated with repetitive transcranial magnetic stimulation on the basis of control group, both two groups were treated for 12 weeks. The clinical efficacy of the two groups was evaluated and compared. The cognitive function (MoCA), life ability (ADL), intelligence state (SIL) and mental and behavioral symptoms (NPI) of the two groups before and after treatment was compared. The adverse reactions of the two groups during treatment were compared. Results The total clinical effective rate was 92.00% in the study group, which was significantly higher than 76.00% in the control group, the difference was statistically significant (P < 0.05). After treatment, the scores of MoCA and SIL in the two groups were higher than those before treatment, and the study group was higher than that in the control group, the differences were statistically significant (P < 0.05). After treatment, the scores of ADL and NPI in the two groups were lower than those before treatment, and the study group was lower than that in the control group, the differences were statistically significant (P < 0.05). There was no statistically difference in the incidence of adverse reactions between the two groups (P > 0.05). Conclusion Quetiapine combined with transcranial magnetic stimulation is effective in the treatment of mental and behavioral symptoms of senile dementia. It can significantly improve the mental and behavioral symptoms, cognitive function, intelligence state and living ability of the patients. It has a high security, and it can provide a reference for clinical treatment.

Key words： Quetiapine Transcranial magnetic stimulation Senile dementia Mental and behavioral symptoms Effect

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	WANG Jindong1 ZHOU Tiantian1 CHEN Xiaoqin2 WANG Bailing1 CUI Weizhen1

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WANG Jindong1 ZHOU Tiantian1 CHEN Xiaoqin2 WANG Bailing1 CUI Weizhen1. Clinical effect of Quetiapine combined with cranial magnetic stimulation on psychobehavioral symptoms of senile dementia[J]. 中国医药导报, 2019, 16(17): 46-49.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I17/46

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