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| Application effect of serum placental growth factor in patients with chronic heart failure |
| WEI Yin HE Yalei CAI Yerui ZHOU Ji ZHANG Xin CHANG Yefei |
| Department of Cardiology, the Third People′s Hospital of Yunnan Province, Yunnan Province, Kunming 650000, China |
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Abstract Objective To study the effect of serum placental growth factor （PlGF） in patients with chronic heart failure, and to provide reference for clinical diagnosis and treatment. Methods Eighty-five patients with chronic heart failure admitted to the Third People′s Hospital of Yunnan Province (“our hospital” for short) from January to March 2015 were selected as the observation group, and 60 healthy patients who participated in the physical examination in our hospital were selected as the control group. Enzyme-linked immunosorbent assay (ELISA) was used to detect the levels of PlGF, hs-CRP and TNF-α in the two groups. The serum indexes of each cardiac function grade were measured. The patients in the observation group were treated symptomatically, and then the changes of serum indexes were compared. Results The serum levels of PlGF, hs-CRP and TNF-α in the observation group were higher than those in the control group before treatment, and the differences were statistically significant (P < 0.05). The serum levels of PlGF, hs-CRP and TNF-α in the observation group increased with the increase of cardiac function grade, and the differences were statistically significant (P < 0.05). The serum levels of PlGF, hs-CRP and TNF-α in the observation group after treatment were lower than those before treatment, and the differences were statistically significant (P < 0.05). Conclusion The serum levels of PlGF, hs-CRP and TNF-α in patients with chronic heart failure are higher than those in healthy people, and increase with the increase of cardiac function grade. Symptomatic treatment can effectively improve the above-mentioned indicators of patients and provide important reference for clinical diagnosis and treatment.
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