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| Study on the clinical effect of Zhikang Granules in the treatment of hyperlipidemia |
| ZHAO Xiumin LI Fengxue GU Jing |
| Department of Integrated Traditional Chinese and Western Internal Medicine, the Second Hospital of Hebei Medical University, Hebei Province, Shijiazhuang 050000, China |
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Abstract Objective To explore the efficacy and safety of combination of Zhikang Granules (ZKG) and Atorvastatin in the treatment of hyperlipidemia. Methods 80 cases of patients with hyperlipidemia treated in the Second Hospital of Hebei Medical University from October 2014 to October 2015 were selected. According to the treatment methods, patients in the control group were treated with Atorvastatin, while on the basis of the control group, patients in the treatment group were treated with ZKG at the same time, with a course of 12 weeks. TC, TG, HDL-C, LDL-C were detected. The therapeutic effect was evaluated. The clinical symptom scores of traditional Chinese medicine were observed. Results After treatment, TG, TC, LDL-C in the treatment group and the control group were all lower than before treatment (P < 0.05), HDL-C in the treatment group was higher than before treatment (P < 0.05). After treatment there were significant differences in TG, TC, LDL-C, HDL-C between the two groups (P < 0.05). The total effective rate of the treatment group was 89.13%, which of the control group was 70.59%, the difference was statistically significant (P < 0.05). Compared with the control group, after treatment the clinical symptom scores of traditional Chinese medicine of lacking in strength, burnout lazy words, numbness of limb, obesity, dry stool in the treatment group were lower, with statistically significant differences (P < 0.05). Conclusion In the treatment of hyperlipidemia by ZKG combined with Atorvastatin is effective and it is better than Atorvastatin alone, which also can improve the clinical symptoms of traditional Chinese medicine.
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[1] 杨华，杨知贵，李小慧.山楂叶总黄酮对高脂血症大鼠血脂和血液流变学的影响[J].中国实验方剂学杂志，2012， 18（12）：257.
[2] Lee SH，Cho KI，Kim JY，et al. Non-lipid effects of rosuvastatinfenofibratecombination therapy in high-risk Asian patients with mixed hyperlipidemia [J]. Atherosclerosis，2012， 221（1）：169-175.
[3] 何海洲，李伯英.脂康颗粒配合非诺贝特治疗高脂血症疗效观察[J].中国循证心血管医学杂志，2015，7（4）：530-532.
[4] 赵福海.脂康颗粒与辛伐他汀降脂治疗随机对照研究[J].中国中西医结合杂志，2010，10（30）：1052-1055.
[5] 王成章.脂康颗粒治疗老年高脂血症80例临床观察[J].华北国防医药，2006，5（18）：341-342.
[6] 刘新宇.脂康颗粒与洛伐他汀联合治疗高脂血症３４例临床研究[J].实用中医内科杂志，2006，4（20）：415-416.
[7] 楼陆军，罗洁霞，高云.山楂的化学成分和药理作用研究概述[J].中国药业，2014，23（3）：92-94.
[8] 王艳，王嵘，赛晓勇，等.体检人群食物不耐受与高脂血症的相关性[J].中华医学杂志，2015，95（2）：126-128.
[9] 陈松婷，戴辉，林爱华.中老年人群高尿酸血症与心血管危险因素关系[J].中国公共卫生，2014，30（2）：144-148.
[10] Andrade IG，Costa-Carvalho BT，Da SR，et al. Risk of ath?鄄erosclerosis in patients with ataxia telangiectasia [J]. Ann NutrMetab，2015，66（4）：196-201.
[11] Assadi F.Allopurinol enhances the blood pressure lowering effectof enalapril in children with hyperuricemic essential hyperlipidaemia [J]. J Nephrol，2014，27（1）：51-56.[12] 万学红，卢雷峰.血液一般检测[M]//诊断学.北京：人民卫生出版社，2014：244-260.
[13] 张淑杰，李淑荣.背俞穴刺血疗法治疗痰瘀互结型高脂血症的临床研究[J].针灸临床杂志，2012，28（10）：41-43.
[14] 李续娥，郭宝江.决明子蛋白质和蒽醌苷对高脂血症大鼠血脂的影响[J].中国中药杂志，2002，27（5）：374-375.
[15] 齐文萱，郑云霞，魏道武，等.红花黄色素对家兔血脂肝功能的影响[J].兰州医学院学报，1987（3）：57.
[16] 雷载权.中药学[M]上海：上海科学技术出版社，2000：205.
[17] 沈奇桂，朱寿明.决明子对实验性高胆固醇血症和动脉粥样硬化的抑制作用及其机理探讨[J].浙江医科大学学报，1993，22（5）：246.
[18] 王敏，范立群，包志宏.体检人群中高尿酸血症与相关疾病的关系[J].武警医学，2012，23（3）： 241-242.
[19] 雷晓林，彭菊，李俊葵，等.迈康片对高脂血症大鼠血管保护的作用机制研究[J].中国实验方剂学杂志，2015， 21（2）：151-155.
[20] 钟冬梅，陈镇涛，连运兴，等.依折麦布联合瑞舒伐他汀在2型糖尿病合并高脂血症患者中的临床研究[J].中国医药科学，2015，5（22）：43-45，177.
[21] 沈映君.中药药理学[M].2版.北京：人民卫生出版社，2011：534-536.
[22] 徐慧平，饶李亮，黄河，等.惠州地区客家人群高尿酸血症并高脂血症患者中医证候流行病学调查[J].中国医药科学，2016，6（14）：155-157，165. |
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