|
|
|
| Curative efficacy of Weifuchun Tablets in combination with Esomeprazol in treating elderly patients with chronic atrophic gastritis and its effects on serum inflammatory factors |
| FAN Chunmei QIAO Jinwan |
| Department of Gastroenterology, the Fifth People′s Hospital of Qinghai Province, Qinghai Province, Xi′ning 810007, China |
|
|
|
|
Abstract Objective To investigate the curative efficacy of Weifuchun Tablets in combination with Esomeprazol in treating elderly patients with chronic atrophic gastritis (CAG) and its effects on serum inflammatory factors. Methods From January to December 2016, 100 elderly patients with CAG in the Department of Gastroenterology, the Fifth People's Hospital of Qinghai Province were selected and divided into control group and observation group by random number table, with 50 cases in each group. Both groups were treated with routine therapy, besides, the control group was treated with Esomeprazole, and the observation group was treated with Weifuchun Tablets based on the control group therapy. The clinical efficacy of the two groups were observed. The levels of serum inflammatory factors between the two groups before and after treatment were compared. The adverse reactions were observed before and after treatment in two groups. Results The total effective rate of the observation group was significantly higher than that of the control group, with statistically significant difference（P < 0.05）.After treatment, the serum inflammatory factors (serum tumor necrosis factor alpha, interleukin 6, interleukin 8, etc.) of two groups were significantly lower than before treatment, with statistically significant difference (P < 0.05). After treatment, the serum inflammatory factors in the observation group were significantly lower than those in the control group, with statistically significant difference (P < 0.05). There were no serious adverse reactions in the two groups of gastritis patients. There were no statistically significant differences at the incidence of adverse reactions in the two groups (P > 0.05). Conclusion Weifuchun Tablets combined with Esomeprazol has well curative efficacy in elderly patients with CAG. And it can increase therapeutic efficiency ratio and alleviate inflammatory reaction with not increasing incidence of adverse reactions.
|
|
|
|
|
|
[1] Rosania R，Varbanova M，Wex T，et al. Regulation of apoptosis is impaired in atrophic gastritis associated with gastric cancer [J]. BMC Gastroenterol，2017，17（1）：84.
[2] 中华中医药学脾胃病分会.慢性萎缩性胃炎中医诊疗共识意见[J].中医杂志，2010，51（8）：749-753.
[3] 刘庭玉，庄雅，党旖旎，等.根除幽门螺杆菌联合叶酸口服3个月治疗慢性萎缩性胃炎的长期随访研究[J].中华消化杂志，2016，36（11）：734-739.
[4] 中华中医药学会脾胃病分会.慢性胃炎中医诊疗专家共识意见[J].中华中医药杂志，2017，32（7）：3060-3064.
[5] Rugge M，Genta RM. Staging and grading of chronic gastritis [J]. Hum Pathol，2005，36：228-233.
[6] Lauwers GY. Defining the pathologie diagnosis of metaplasia，atrophy，dysplasia，and gastric adenocarcinoma [J]. J Clin Gastroenterol，2013，36（5 Suppl）：S37-S43.
[7] 金华江.中药联合埃索美拉唑治疗慢性萎缩性胃炎临床观察[J].吉林中医药，2012，32（7）：690-691.
[8] 邵学军.胃复春片联合雷贝拉唑钠肠溶片治疗慢性胃炎伴反流性食管炎的临床观察[J].中国药房，2016，27（6）：752-755.
[9] 杨晋翔，安静，彭继升，等.半夏泻心汤加减方治疗慢性萎缩性胃炎临床疗效的系统评价[J].北京中医药大学学报，2015，38（1）：46-52.
[10] 王萍.慢性萎缩性胃炎中医证治规律探讨及临床疗效评价研究[D].北京：中国中医科学院，2008.
[11] Jeong S，Choi E，Petersen CP，et al. Distinct metaplastic and inflammatory phenotypes in autoimmune and adenocarcinoma-associated chronic atrophic gastritis [J]. United European Gastroenterol J，2017，5（1）：37-44.
[12] 张峰，王卫国，谢燕，等.慢性萎缩性胃炎胃镜与病理诊断的符合率及与Hp感染的相关性分析[J].临床和实验医学杂志，2016，15（23）：2325-2327.
[13] 陈国荣，郭振科，李志坚，等.复方消化酶联合埃索美拉唑治疗对胃食管反流病伴消化不良临床疗效及安全分析[J].内蒙古医学杂志，2017，49（3）：276-278.
[14] 贺慧鹏，陈维顺.埃索美拉唑三联疗法治疗胃溃疡合并Hp感染的疗效观察[J].中国现代医生，2015，53（4）：23-25.
[15] 马善美，陈本华.半夏泻心汤联合埃索美拉唑治疗慢性萎缩性胃炎的临床疗效观察[J].世界中医药，2015，10（10）：1515-1517，1521.
[16] 谢妲.荆花胃康胶丸联合摩罗丹治疗老年慢性萎缩性胃炎伴Hp感染临床疗效及对胃镜组织学的影响[J].河北医学，2017，23（3）：412-415.
[17] 李志茹，王滨，杨巧芳，等.中医诊治慢性萎缩性胃炎的研究概况及进展[J].内蒙古医科大学学报，2016，38（4）：370-374.
[18] 申兰国，曹志群.苦参碱联合胃复春片治疗慢性萎缩性胃炎患者的疗效研究[J].实用药物与临床，2016，19（7）：883-885.
[19] 曹丽君，阳学风.胃复春替普瑞酮联合治疗慢性萎缩性胃炎[J].南华大学学报：医学版，2008，36（5）：617-619.
[20] 吕振军，吕素珍，翟玉馨，等.胃复春片与养阴活胃中药合剂治疗萎缩性胃炎疗效比较[J].现代中西医结合杂志，2014，23（34）：3804-3805.
[21] 陈佳，李守英，徐红，等.慢性萎缩性胃炎的研究进展[J].中国老年学杂志，2013，33（14）：3540-3542.
[22] 邱志洁，伊春锦，李新民，等.一贯煎加减对慢性萎缩性胃炎IL-12和TNF-α的影响[J].中国实验方剂学杂志，2012，18（11）：248-250.
[23] 李多，杜三军，于永强.白术内酯I对慢性萎缩性胃炎大鼠相关炎性因子的影响[J].解放军医药杂志，2016， 28（8）：10-14.
[24] 王丽华.益胃活络经验方联合三联疗法对胃络瘀血证慢性萎缩性胃炎患者胃黏膜腺体及血清炎性因子的影响[J].陕西中医，2016，37（1）：48-50.
[25] 陶梅，张沥，张玲霞，等.实验性萎缩性胃炎大鼠细胞因子IL-6、IL-8的变化及意义[J].山西医科大学学报，2010， 41（8）：673-676. |
|
|
|
