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| Comparison of effect, T lymphocyte subsets and quality of life between laparoscopic extraperitoneal radical prostatectomy and prostatectomy by open surgery in patients with prostate cancer |
| LI Zhikun TANG Lei ZHAO Yawei MA Liujiang MA Wang |
| Department of Urology, Xinjiang Production and Construction Corps Hospital Second Hospital Affiliated Medical School of Shihezi University, Xinjiang Uygur Autonomous Region, Urumqi 830002, China |
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Abstract Objective To compare the effect, T lymphocyte subsets and quality of life between laparoscopic extraperitoneal radical prostatectomy and prostatectomy by open surgery in patients with prostate cancer. Methods From January to Dctober 2016, in Department of Urology, Xinjiang Production and Construction Corps Hospital, 105 patients with prostate cancer were selected, they were divided into the open surgery group (n = 45) and the laparoscope group (n = 60) according to operation methods. The open surgery group was given prostatectomy by open surgery, the laparoscope group was given laparoscopic extraperitoneal radical prostatectomy. International prostate symptom score (IPSS) and core quality of life questionnaire-30 (QLQ-C30) were employed to assess severity of clinical symptoms and quality of life. Then, the operation status, efficacy-related indices, lymphocyte subsets and quality of life were compared. Results All patients underwent successful operation, and the incidences of postoperative complications in the open surgery group and the laparoscope group were compared, the differences were not statistically significant (P > 0.05). 1 month after surgery, scores of IPSS, maximum urine flow rate, residual urine volume and levels of prostate specific antigen of the two groups were compared, the differences were not statistically significant (P > 0.05). Compared with the open surgery group, the laparoscope group had higher levels of CD4＋, CD4＋/ CD8＋ and lower level of CD8＋, the differences were statistically significant (P < 0.05). 1 month after surgery, compared with the open surgery group, scores of role function, emotional function and social function that reflected quality of life in laparoscope group were statistically higher,(all P < 0.05), the differences were statistically significant (P < 0.05). but scores of body function and cognitive function in the two groups were compared, the differences were not statistically significant (P > 0.05). Conclusion Both laparoscopic extraperitoneal radical prostatectomy and prostatectomy by open surgery are effective and safely operation modes for patients with prostate cancer. Compared with open surgery, laparoscopic extraperitoneal radical prostatectomy has less influence on cellular immune function and improves quality of life more after operation. For patients who are suitable for laparoscopic extraperitoneal radical prostatectomy, this operation mode is priority selection.
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