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| Comparison of clinical effect between Lamotrigine and Carbamazepine in the treatment of trigeminal neuralgia |
| TAN Zhiyong MA Yanfang |
| Department of Emergency, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China |
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Abstract Objective To explore the clinical effect between Lamotrigine and Carbamazepine in the treatment of trigeminal neuralgia. Methods 120 cases of patients with trigeminal neuralgia treated in Beijing Ditan Hospital, Capital Medical University from July 2014 to July 2016 were selected. Patients were divided into the Lamotrigine group and the Carbamazepine group by the random number table, each group had 60 cases. Patients in the Lamotrigine group and the Carbamazepine group were respectively given Lamotrigine and Carbamazepine treatment. VAS score, laboratory test indexes and changes of immunoglobulin levels in the cerebrospinal fluid were compared and analyzed between the two groups. Results VAS scores in 1 and 3 months after treatment in the Lamotrigine group were lower than those in the Carbamazepine group, with statistically significant differences (P < 0.05). Counts of cerebrospinal fluid cell and white blood cell after treatment in the Lamotrigine group were lower than those in the Carbamazepine group, with statistically significant differences (P < 0.05). Levels of IgG, IgA, IgM of patients after treatment in the Lamotrigine group were lower than those in the Carbamazepine group, with statistically significant differences (P < 0.05). Conclusion Lamotrigine in the treatment of trigeminal neuralgia has a significant effect, obviously better than Carbamazepine treatment, which can promote the improvement of laboratory test results, relieve pain and also improve the immune function of cerebrospinal fluid. It has great clinical significance.
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