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Clinical analysis of acute cerebrovascular disease combined with cerebro-cardiac syndrome in 125 cases of middle-aged and elderly |
WANG Shuyin WANG Yishu LI Yun WANG Weili▲ |
Department of General Medical, Beijing Xiaotangshan Hospital, Beijing 102211, China |
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Abstract Objective To discuss the incidence, influential factors, clinical characteristics and preventive measures of cerebro-cardiac syndrome (CCS) in acute cerebrovascular disease (ACVD) patients of middle-aged and elderly. Methods The clinical data of 204 patients with ACVD treated in Beijing Xiaotangshan Hospital from October 2000 to October 2016 were analyzed retrospectively. The disease types, location, changes of electrocardiogram & myocardial enzymes, biochemical indexes, treatment and prognosis were observed. Results There were 125 cases combined with CCS, with incidence of 61.3%. There were 76 male and 49 female. The incidence of CCS in hemorrhagic cerebrovascular disease (intracerebral hemorrhage and subarachnoid hemorrhage) was significantly higher than that in ischemic cerebrovascular disease, with statistically significant difference (P < 0.01). The incidence of CCS in deep brain lesions (brain stem and cerebellum, thalamus and basal ganglia) was significantly higher than that in cerebral hemisphere lesions, with statistically significant difference (P < 0.01). Patients with CCS had electrocardiogram changes, including myocardial ischemia change, various arrhythmia. The results of laboratory examination showed that elevated myocardial enzymes, abnormal electrolyte and pathoglycemia. Mortality of the patients combined with CCS was significantly higher than that of patients without CCS (P < 0.01). Conclusion The occurrence of CCS is related with the disease types, location and outcomes of the disease. There is a guiding significance for the prognosis judgment of patients with ACVD and correct therapy by grasping the clinical characteristics of CCS.
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[1] 王晓莉,张维文,孟伟健,等.急性脑卒中伴发脑心综合征临床分析[J].中国实用神经疾病杂志,2015,18(24):95-96.
[2] 李陈,刘敏,王振宇,等.急性脑卒中患者发生脑心综合征的相关分析及其预后研究[J].重庆医学,2014,43(14):1732-1733.
[3] Thom T,Haase N,Rosamond W,et al. Heart disease and stroke statistics-2006 update a report from the American Heart Association statistics Committee and stroke Statistics Sub committee [J]. Circulation,2006,113(6):e85-e151.
[4] 苏丽娜.急性脑血管病致脑心综合征心电图改变的临床观察[J].临床医学研究与实践,2016,1(7):7-8.
[5] 孙至善,孟然,冯兴中,等.脑心综合征对急性缺血性脑卒中预后评价的临床意义[J].中华临床医学杂志:电子版,2013,7(11):39-41.
[6] 中华医学会全国第四次脑血管病学术会议.各类脑血管疾病诊断要点[J].中华神经科杂志,1996,29(6):379-381.
[7] Lindgren A,Wohlfart B,Pahlm O. Electrocardioraphic changes in strok patiends without primary heart disease [J]. Clin Physiol,1994,14:223.
[8] 许世锋.急性脑血管病致脑心综合征心电图改变的特点分析[J].心血管病防治知识,2016(10):74-75.
[9] 陈禺,储伟.脑心综合征的研究进展[J].江苏实用心电学杂志,2013,22(2):614-616.
[10] 王亚峰,钟海江.急性脑血管病并发脑心综合征临床观察[J].心脑血管病防治,2010,10(2):113-114.
[11] Oppenheimer SM,Wilson JX,Gruiraudon C,et al. Insular cortex stimulation produces Lethal cardiac arrhythmias:A mechanism of sudden death? [J]. Brain Res,1991,550(1):115-121.
[12] 成辉.急性脑血管病致脑心综合征心电图改变的特点分析[J].黑龙江医学,2013,37(12):1225.
[13] 王允琴,戴秀珍,徐磊,等.脑心综合征的发病机制及其临床理化特征[J].中医药临床杂志,2014,26(11):1185-1186.
[14] Cehetto DF. Experimental Cerebral Ischanic Lesions of Autonomic and cardiac effects in Cats and Rats [J]. Stroke,1993,24(suppl):6-9.
[15] Frontera JA,Parra A,Shimbo D,et al. Cardiac arrhythmias after subarachnoid hemorrhage:risk factors and impact on outcome [J]. Cerebrovasc Dis,2008,26(1):71-78.
[16] Bone R. ACCP/SCCM consensus conference:Definition for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis [J]. Chest,1992,101(1):864-874.
[17] 袁鹏,王海云,刘贤修.急性脑卒中并发脑心综合征80例临床分析[J].山东医药,2013,53(22):76-77.
[18] 胡锦全,李贞艳,张跃亮,等.脑出血并发脑心综合征的临床分析[J].中国实用神经疾病杂志,2013,16(24):38-39.
[19] Daniele O,Caravaglios G,Fierro B,et al. Stroke and cardiac arrhythmias [J]. J Stroke and Cerebrovas Dis,2002, 11(1):28.
[20] 黎明丽,宋薇,胡汉昆,等.甘油果糖注射液对比甘露醇注射液治疗脑水肿疗效和安全性的Meta分析[J].中国药房,2014 ,25(44):4140-4143.
[21] Fredrik P,Austari J. Early Hemodynamic Changes in Experi 2 mental Intracerebral Hemorrhage [J]. J Neurosurg,1986,65(11):697. |
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