急性冠脉综合征患者B型利钠肽与全球急性冠状动脉事件注册评分的相关性

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Abstract Objective To investigate the correlation between brain natriuretic peptide (BNP) level and global registry of acute coronary events (GRACE) risk score in patients with acute coronary syndrome (ACS). Methods One hundred and four patients with ACS admitted to Beijing Tiantan Hospital, Capital Medical University from June 2015 to August 2016 were selected. According to GRACE risk score, the patients with ACS were divided into low risk (GRACE: ≤108 points), intermediate (GRACE: 109-140 points) and high (GRACE: ＞140 points) 3 groups, the levels of BNP in each subgroup were detected. According to the BNP level, the patients were divided into 4 groups from Q1 to Q4, and the GRACE scores and high-risk percentages were calculated. The correlation between BNP and GRACE score was analyzed. Receiver operating characteristic (ROC) was used to analyze the area under the curve of BNP level and GRACE risk score for major adverse cardiac events (MACE) in patients with ACS during hospitalization, and to evaluate its predictive value. Results Among the 3 subgroups of ACS, the BNP in high risk group was higher than the middle risk group (P ＜ 0.05) and the low risk group (P ＜ 0.01), the differences were statistically significant. The GRACE score and high-risk percentage in group Q4 were higher than those in groups under Q4 (P ＜ 0.05). Correlation analysis showed that BNP results were positively correlated with GRACE score (r = 0.448, P ＜ 0.01). The area under the curve of baseline BNP level and GRACE score for ACS patients during hospitalization was 0.677 and 0.745, respectively, the difference was statistically significant (P ＜ 0.05). Conclusion Both BNP level and GRACE score can predict the occurrence of MACE in ACS patients during hospitalization, which may be an important prognostic indicator for ACS patients.

Key words： Acute coronary syndrome Brain natriuretic peptide Global registry of acute coronary events Major adverse cardiac events

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	LI Jingwei1▲ WANG Hong2 DU Fenghe1 XU Xiuying1 TIAN Junping1▲

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LI Jingwei1▲ WANG Hong2 DU Fenghe1 XU Xiuying1 TIAN Junping1▲. Association between interleukin-6 and global registry of acute coronary events score in patients with acute coronary syndrome[J]. 中国医药导报, 2017, 14(20): 54-57.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2017/V14/I20/54

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