|
|
|
| Study progress of tissue-engineered cartilage in repairing cartilage defect |
| ZHANG Zhijin1 ZENG Linru2 ZHU Fangbing3 GUO Lin4 |
1.Eleven Ward Two Department of Hand Surgery, Xiaoshan District Hospital of Traditional Chinese Medicine of Hangzhou City, Zhejiang Province, Hangzhou 311201, China;
2.Department of Ankle Surgery, Xiaoshan District Hospital of Traditional Chinese Medicine of Hangzhou City, Zhejiang Province, Hangzhou 311201, China; 3.Department of Sports Medicine, Xiaoshan District Hospital of Traditional Chinese Medicine of Hangzhou City, Zhejiang Province, Hangzhou 311201, China; 4.Department of Joint Surgery, Zhongshan Hospital Affiliated to Dalian University, Liaoning Province, Dalian 116001, China |
|
|
|
Abstract The pain and joint movement disorder caused by articular cartilage defects have seriously affected the quality of life of patients. The application of tissue engineering technology in the repair of cartilage defects has become a hot topic in research, which provides a new idea for its treatment. In this paper, we review the research progress of tissue engineering to repair cartilage defects on the basis of the requirements, sources and methods of seed cells, the requirements and types of biological scaffold, and the regulation of cell growth factors.
|
|
|
|
|
|
[1] Sittinger M，Bujia J，Rotter N，et al. Tissue engineering and autologous transplant formation：practical approaches with resorbable biomaterials and new cell culture techniques [J]. Biomaterials，1996，17（3）：237.
[2] Marijnissen WJ，van Osch GJ，Aigner J，et al. Alginate as a chondrocyte-delivery substance in combination with a non-woven scaffold for cartilage tissue engineering [J]. Biomaterials，2002，23（6）：1511.
[3] Gobbi A，Nunag P，Malinowski K. Treatment of full thickness chondral lesions of the knee with microfracture in a group of athletes [J]. Knee Surg Sports Traumatol Arthrosc，2005，13（3）：213-221.
[4] Widuchowski W，Widuchowski J，Trzaska T. Articular cartilage defects：study of 25，124 knee arthroscopies [J]. Knee，2007，14（3）：177-182.
[5] Gross AE，Agnidis Z，Hutchison CR. Osteochondral defects of the talus treated with fresh osteochondral allograft transplantation [J]. Foot Ankle Int，2001，22（5）：385.
[6] Langer R. Tissue engineering [J]. Science，2000，260（5110）：920-926.
[7] 丛波，张仲文.软骨组织工程种子细胞源的研究进展[J].中华灾害救援医学，2016，4（6）：341-344.
[8] Angele P，Yoo JU，Smith C，et al. Cyclic hydrostatic pressure enhances the chondrogenic phenotype of human mesenchymal progenitor cells differentiated in vitro [J]. J Orthop Res，2003，21（3）：451-457.
[9] Worster AA，Brower-Toland BD，Fortier LA，et al. Chondrocytic differentiation of mesenchymal stem cells sequentially exposed to transforming growth factor-beta1 in monolayer and insulin-like growth factor-I in a three-dimensional matrix [J]. J Orthop Res，2001，19（4）：738.
[10] Campbell JJ，Lee DA，Bader DL. Dynamic compressive strain influences chondrogenic gene expression in human mesenchymal stem cells [J]. Biorheology，2006，43（3-4）：455-470.
[11] 张仲文，侯世科，杨造成，等.基质诱导的自体软骨细胞移植术修复膝关节软骨缺损10例术后2年的随访[J].中华关节外科杂志：电子版，2010，4（6）：734-741.
[12] Koga H，Engebretsen L，Brinchmann JE，et al. Mesenchymal stem cell-based therapy for cartilage repair：a review [J]. Knee Surg Sports Traumatol Arthrosc，2009，17（11）：1289-1297.
[13] Lu FZ，Fujino M，Kitazawa Y，et al. Characterization and gene transfer in mesenchymal stem cells derived from human umbilical-cord blood [J]. J Laboratory Clin Med，2005，146（5）：271-278.
[14] Grande DA，Mason J，Light E，et al. Stem cells as platforms for delivery of genes to enhance cartilage repair [J]. J Bone Joint Surg，2003，85（1）：111-116.
[15] 陈佳琦，陈慧敏.间充质干细胞的研究现状与应用前景[J].北京生物医学工程，2015，34（4）：435-438.
[16] Abdallah BM，Kassem M. Human mesenchymal stem cells：from basic biology to clinical applications [J]. Gene Ther，2008，15（2）：109-116.
[17] Kuroda R，Usas A，Kubo S，et al. Cartilage repair using bone morphogenetic protein 4 and muscle-derived stem cells [J]. Arthrit Rheumat，2006，54（2）：433-442.
[18] 李丹，周广东，刘涓，等.骨髓间充质干细胞体外构建组织工程化半月板[J].组织工程与重建外科杂志，2013，9（5）：251-255.
[19] Murphy JM，Dixon K，Beck S，et al. Reduced chondrogenic and adipogenic activity of mesenchymal stem cells from patients with advanced osteoarthritis [J]. Arthrit Rheumat，2002，46（3）：704-713.
[20] 孙鹏浩.软骨细胞和骨髓间充质干细胞体外共培养的成瘤危险性的研究[D].南京：东南大学，2014.
[21] Estes BT，Diekman BO，Gimble JM，et al. Isolation of adipose-derived stem cells and their induction to a chondrogenic phenotype [J]. Nat Protocol，2010，5（7）：1294-1311.
[22] Winter A，Breit S，Parsch D，et al. Cartilage-like gene expression in differentiated human stem cell spheroids：a comparison of bone marrow–derived and adipose tissue-derived stromal cells [J]. Arthrit Rheumatol，2003， 48（2）：418-429.
[23] Wakitani S，Aoki H，Harada Y，et al. Embryonic stem cells form articular cartilage，not teratomas，in osteochondral defects of rat joints [J]. Cell Transplant，2004，13（4）：331-336.
[24] Kramer J，B?觟hrnsen F，Schlenke P，et al. Stem cell-derived chondrocytes for regenerative medicine [J]. Transplant Proceed，2006，38（3）：762-765.
[25] Ringe J，Kaps C，Burmester GR，et al. Stem cells for regenerative medicine：advances in the engineering of tissues and organs [J]. Sci Nat，2002，89（8）：338-351.
[26] Lee CR，Grodzinsky AJ，Spector M. Biosynthetic response of passaged chondrocytes in a type Ⅱ collagen scaffold to mechanical compression [J]. J Biomed Mater Res，2003， 64（3）：560.
[27] 张永涛.不连通双层PLGA支架负载自体骨髓间充质干细胞与富血小板血浆的复合体修复骨软骨缺损的实验研究[D].广州：南方医科大学，2013.
[28] 张旭东，逯卓卉，陈伟，等.用组织工程学方法探讨兔佐剂性关节炎关节软骨修复的实验研究[J].北京生物医学工程，2016，35（2）：185-190.
[29] 于洪宇，马春雨.壳聚糖-胶原凝胶复合骨髓间充质干细胞修复兔关节软骨缺损的组织学变化[J].中国组织工程研究，2010，14（25）：4581-4584.
[30] 林涛，陈竹，袁德超，等.壳聚糖水凝胶复合脂肪间充质干细胞修复兔关节软骨缺损[J].中华创伤杂志，2016， 32（4）：357-362.
[31] 杨自权，何君仁，李刚，等.可塑形脱细胞软骨基质材料的制备及性状研究[J].中国修复重建外科杂志，2008， 22（10）：1232-1237.
[32] Augst AD，Kong HJ，Mooney DJ. Alginate hydrogels as biomaterials [J]. Macromol Biosci，2006，6（8）：623-633.
[33] Adachi T，Osako Y，Tanaka M，et al. Framework for optimal design of porous scaffold microstructure by computational simulation of bone regeneration [J]. Biomaterials，2006，27（21）：3964-3972.
[34] 陈哲峰，范卫民，刘峰.利用PLA、PGA、PLGA三种支架再生兔关节软骨[J].江苏医药，2005，31（8）：599-601.
[35] Vacanti CA，Langer R，Schloo B，et al. Synthetic polymers seeded with chondrocytes provide a template for new cartilage formation [J]. Plast Reconstr Surg，1991，88（5）：753-759.
[36] 刘建斌.壳聚糖-明胶/β-磷酸三钙复合体作为组织工程软骨支架材料的实验研究[J].组织工程与重建外科杂志，2010，6（6）：319-322.
[37] Dan K，Prabhakaran MP，Benjamin S，et al. Mechanical properties and，in vitro behavior of nanofiber-hydrogel composites for tissue engineering applications[J]. Nanotechnology，2012，23（9）：095705.
[38] Thorpe SD，Buckley CT，Vinardell T，et al. The response of bone marrow-derived mesenchymal stem cells to dynamic compression following TGF-β3 induced chondrogenic differentiation [J]. Ann Biomed Engineering，2010， 38（9）：2896-2909.
[39] Bosnakovski D，Mizuno M，Kim G，et al. Chondrogenic differentiation of bovine bone marrow mesenchymal stem cells（MSCs）in different hydrogels：influence of collagen type Ⅱ extracellular matrix on MSC chondrogenesis [J]. Biotechnol Bioengineering，2006，93（6）：1152-1163.
[40] 同志超，杨镇，同志勤，等.骨髓间质干细胞体外定向诱导分化为软骨细胞的实验研究[J].中国骨伤，2008，21（5）：362-364.
[41] Nixon AJ，Goodrich LR，Scimeca MS，et al. Gene therapy in musculoskeletal repair [J]. Ann New York Acad Sci，2007， 1117（1）：310-327.
[42] 付勤，王勇，于冬冬，等.外源性TGF-β1及IGF-1诱导大鼠脂肪干细胞向软骨细胞分化的实验研究[J].中国骨质疏松杂志，2007，13（12）：848-853.
[43] Hanada K，Solchaga LA，Caplan AI，et al. BMP-2 induction and TGF-beta 1 modulation of rat periosteal cell chondrogenesis [J]. J Cell Biochem，2001，81（2）：284-294.
[44] Matsumoto T，Kubo S，Meszaros LB，et al. The influence of sex on the chondrogenic potential of muscle-derived stem cells：implications for cartilage regeneration and repair [J]. Arthrit Rheumat，2008，58（12）：3809-3819.
[45] Guo XD，Du JY，Zheng QX，et al. Neocartilage formation in vitro using transduced mesenchymal stem cells cultured on biomimetic biodegradable polymer scaffolds [J]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao，2001，23（4）：373-377. |
|
|
|
