|
|
|
| Susceptibility-weighted imaging of clinical application of brain iron depositionin in patients with Parkinson disease |
| HE Juan1 Huriletemuer1 HAN Xiaodong2 SUN Ming1 ZHANG Chunyu1 DUAN Meiqing3 WANG Zhiguang1 ZHANG Guohua1 LIU Guiying1 |
| 1.Department of Neurology, Affiliated Hospital of Inner Mongolia Medical University, Inner Mongolia Autonomous Region, Hohhot 010059, China; 2.Department of Radiology, Affiliated Hospital of Inner Mongolia Medical University, Inner Mongolia Autonomous Region, Hohhot 010059, China; 3.Department of Laboratory, Affiliated Hospital of Inner Mongolia Medical University, Inner Mongolia Autonomous Region, Hohhot 010059, China |
|
|
|
|
Abstract Objective To clinical value of iron deposition in brain of Parkinson disease (PD) by susceptibility weighted imaging (SWI). Methods From June 2010 to June 2016, in Department of Neurology, Affiliated Hospital of Inner Mongolia Medical University, 40 PD patients were selected as PD group, 20 healthy volunteers were enrolled into the control group (NC group) at the same time. All PD patients were graded by Hoehn&Yahr, stage≤1.5 as early phase group (PD1 group) 23 cases, stage > 1.5 as middle and advanced phase (PD2 group) 17 cases. brain nuclei of each group were examinated by MRI and SWI with 3.0TMR system, and the results were compared and analyzed. Results The phase values of caudate nucleus (CN), globus pallidus (GP), putamen (PU), red nucleus (RN) and substantia nigra (SN) of patients in PD group increased compared with NC group, which indicated there was more iron deposits. The phase values of SN, GP and RN in PD1 group, PD2 group and NC group were compared, the differences were statistically significant (P < 0.05), but the phase values of PU, CN in three groups were compared, the differences were not statistically significant (P > 0.05); the phase values of SN, GP, CN in PD2 group were compared with NC group, the differences were statistically significant (P < 0.05), but these in PD1 group and PD2 group were compared, the differences were not statistically significant (P > 0.05). Conclusion SWI can reflect the iron deposition in the brain, and it can be used to evaluate the brain iron deposition by measuring the signal intensity of related brain nuclei and calculating the phase value. It can provide some help for diagnosis and treatment of the patients.
|
|
|
|
|
|
[1] 王书健，邓克学，郑春生，等. SWI测量脑铁沉积在帕金森病中的临床应用价值[J].安徽医科大学学报，2013,48（5）：523-526.
[2] Atasoy HT，Nuyan O，Tunc T，et al. T2-weighted MRI in Parkinson，s disease;Substantia nigra parscompacta hypointensity correlateswwith the clinjical scores [J]. Neurol India，2004，52（3）：332-337.
[3] Lonneke ML，Monique MB. Epidemiology of Parkinson′s disease [J]. Lancet Neurol，2006;5（6）：525-535.
[4] 任延德，龙莉玲，李向荣，等.磁敏感加权成像检测帕金森病患者黑质铁含量[J].广西医学，2016，38（6）：770-772.
[5] Gelb DJ，Oliver E，Gilman S. Diagnostic criteria for Parkinson，s disease [J]. Arch Neurol，1999，56（1）：33-39.
[6] 舒红格，漆剑频.帕金森病的扩散张量成像研究[J].中国医学影像技术，2010，26（4）：643-645.
[7] Kaur D，Peng J，Chinta SJ，et al. Inereased murine neonatal iron intake results in Parkinson-like neurodegeneration with age [J]. Neurobiol Aging，2007，28：907.
[8] 万华，李春华，赵年.磁敏感加权成像技术在帕金森病患者的脑基底节和红核铁含量的变化分析中的应用研究[J].临床和实验医学杂志，2015，14（8）：628-630.
[9] Liu TY，Bai Y，Ma XY，et al. The value of “swallow tail” appearance of nigrosome on ESWAN at 3.0T MR in the diagnosis of Parkinson′s disease [J]. Chin J Magn Reson Imaging，2016，7（46）：265-269.
[10] 王慈，范国光，刘芳，等.磁敏感加权成像中脑定量测量在帕金森病中的初步应用[J].中国医学影像技术，2011， 27（6）：1129-1133.
[11] Yoon RG，Kim SJ，Kim HS，et al. The utility of susceptibility-weighted imaging for differentiating Parkinsonism-predominant multiple system atrophy from Parkinson disease ：correlation with 18F-flurodeox-yglucose positron-emission tomography [J]. Neurosci Lett，2015，1（584）：296-301.
[12] 杨威.脑铁含量与帕金森病的关系分析[J].临床合理用药，2016，9（8）：104-105.
[13] 江名芳，牛广明，高阳，等.帕金森病脑铁沉积的定量研究[J].医学影像学杂志.2016，26（5）：762-767.
[14] Tea-Hyoung Kim， Jae-Hyeok Lee. Serum uric acid and nigral iron deposition in Parkinson′s disease：a pilot study [J]. PLoS One，2014，9（11）：e112512.
[15] Wu SF，Zhu ZF，Kong Y，et al. Assessment of cerebral iron content in patients with Parkinson disease by the susceptibility-weighted MRI [J]. Eur Rev Med Pharmacol Sci，2014，18 （18）：2605-2608.
[16] Zhang J，Wang J. Characterizing iron deposition in Parkinson disease using suseeptibility- weighted imaging：an invivo MR study [J]. Brain Res，2010，13（30）：124-130.
[17] Haacke EM，Cheng YC，Ogg RJ，et al. Imaging iron stores in the brain using magnetic resonance imaging [J]. Magn Reson Imaging，2005，23（1）：1-25.
[18] 杨江胜，朱祖福，高志强，等.磁敏感加权成像在测定帕金森病脑铁沉积中的临床应用[J].中国老年学杂志，2015，35（6）：3368-3369.
[19] 王波，安鸿飞，张杰，等.3.0TMR磁敏感加权成像对早期帕金森病黑质致密带的研究[J].昆明医科大学学报，2014，35（2）：27-30.
[20] Berg D，Hochstrasser H. Iron metabolism in Parkinsonian syndromes [J]. Mov Disord，2006，21：1299-1310.
[21] 王劲.MRI检测帕金森病脑铁含量的研究进展[J].国外医学：神经病学·临床放射学分册，2002，29（6）：556-559. |
|
|
|
