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| Relationship between serum sex hormone level and Th1/Th2 balance and endothelial function in perimenopausal women |
| YANG Xueming1 CHEN Zongyao2 WANG Dengchao2 |
1.Department of Clinical Laboratory, Maternal and Child Health Hospital of Deyang City, Sichuan Province, Deyang 618000, China;
2.Department of Clinical Laboratory, People′s Hospital of Deyang City, Sichuan Province, Deyang 618099, China |
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Abstract Objective To study the relationship between serum sex hormone level and Th1/Th2 balance and endothelial function in perimenopausal women. Methods 40 perimenopausal women admitted in Deyang Maternal and Child Health Hospital in Sichuan Province ("our hospital" for short) from March 2016 to March 2018 were selected as perimenopausal group, 40 menopausal women served as menopausal group. At the same time, 40 healthy women who underwent physical examination in our hospital served as normal control group. The level of serum sex hormone, Th1/Th2 related cytokines and endothelial injury markers was compared among three groups of women, and their correlation was analyzed. Results The level of serum estradiol (E2) in normal control group, perimenopausal group and menopausal group decreased gradually. The level of serum follicle stimulating hormone (FSH) increased gradually, and the difference of serum E2 and FSH among three groups was significant (P < 0.05). Serum level of interleukin-2 (IL-2) and interferon-γ (IFN-γ) increased gradually in normal control group, perimenopausal group and menopausal group, while level of IL-4 and IL-10 decreased gradually. There was significant difference in serum level of IL-2, IFN-γ, IL-4 and IL-10 between each group (P < 0.05). The level of serum nitric oxide (NO) decreased gradually in normal control group, perimenopausal group and menopausal group, while the level of serum endothelin-1 (ET-1) increased gradually. There was significant difference in NO and ET-1 among groups (P < 0.05). Pearson correlation analysis showed that serum E2 was negatively correlated with IL-2, IFN-γ and ET-1, but positively correlated with IL-4, IL-10 and NO in perimenopausal women. Serum FSH was positively correlated with IL-2, IFN-γ and ET-1, but negatively correlated with IL-4, IL-10 and NO (all P < 0.05). Conclusion Serum sex hormone level in perimenopausal women may affect Th1/Th2 balance and lead to endothelial dysfunction.
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