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| Changes and clinical significance of serum thyrotropin and thyroid peroxidase antibody level in patients with intrahepatic cholestasis in pregnancy |
| PANG Liansheng ZHAO Wanchun |
| Department of Clinical Laboratory, the Second People′s Hospital of Jingzhou City, Hubei Province, Jingzhou 434000, China |
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Abstract Objective To investigate the changes and clinical significance of serum thyrotropin (TSH) and thyroid peroxidase antibody (TPOAb) level in patients with intrahepatic cholestasis in pregnancy (ICP). Methods A total of 120 patients with ICP admitted to the Second People′s Hospital of Jingzhou City in Hubei Province ("our hospital" for short) from March 2015 to March 2017 was selected as observation group. The patients of observation group were divided into mild group (n = 59) and severe group (n = 61) according to the severity of ICP. Another 60 healthy pregnant women who had normal physical examination in our hospital during the same period were selected as control group. The serum TSH and TPOAb level was measured by enzyme-linked immunosorbent assay. The serum TSH and TPOAb level of control group and observation group was compared. Change of serum TSH and TPOAb level of the pregnant women with different severity of ICP was compared. Pearson correlation analysis was used to analyze the correlation between serum TSH and TPOAb. The incidence of neonatal complications and adverse pregnancy outcomes in control group and observation group was recorded. Results The serum TSH and TPOAb levels in observation group were significantly higher than those in control group, the differences were statistically significant (P < 0.05). The serum TSH and TPOAb levels of severe group were higher than those in mild group, the differences were statistically significant (P < 0.05). The total incidence of neonatal complications and adverse pregnancy outcomes in observation group were higher than those in control group, the differences were statistically significant (P < 0.05). Pearson correlation analysis showed that serum TSH and TPOAb was positively correlated with the severity of ICP (r = 0.532, 0.503, P < 0.05). Conclusion The level of serum TSH and TPOAb of ICP patients is highly expressed. With the aggravation of ICP, the level of TSH and TPOAb increased continuously. The above serological indicators can be considered as one of the biological indicators for the diagnosis of ICP.
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