慢性心力衰竭患者血清TNF-■、BNP、Cys-C水平与心肾功能的关系

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Abstract Objective To investigate the level of serum tumor necrosis factor-α (TNF-α), brain natriuretic peptide (BNP) and cystatin-C (Cys-C) in patients with chronic heart failure (CHF) and their relationship with heart-kidney function. Methods Niney-five cases of patients with CHF in the Third People′s Hospital of Chengdu City in Sichuan Province from July 2016 to July 2018 were selected as study group, in addition, 68 cases of healthy volunteers in same physical examination center were selected as control group. Serum levels of TNF-α, BNP and Cys-C were measured by enzyme-linked immunosorbent assay, and left ventricular end-diastolic diameter (LVEDD), left ventricular ejection fraction (LVEF) and left ventricular mass index (LVMI) were measured by color Doppler ultrasonic unit. Renal function related indicators were also detected，included serum creatinine (Scr), blood urea nitrogen (BUN) and glomerular filtration rate (GFR). The correlation between serum biological indicators and heart-kidney function indexes was analyzed. Results The serum levels of TNF-α, BNP, Cys-C, LVEDD, LVMI, Scr and BUN in study group were significantly higher than those in control group, while the levels of LVEF and GFR in study group were significantly lower than those in control group, the differences were statistically significant (P < 0.05). With the increase of cardiac function and the aggravation of renal function, the levels of TNF-α, BNP and Cys-C of patients with CHF increased significantly, the differences were statistically significant (P < 0.05). The levels of TNF-α, BNP and Cys-C were positively correlated with LVEDD, LVMI, Scr and BUN (P < 0.05), but negatively correlated with LVEF and GFR (P < 0.05). Conclusion The elevation of serum TNF-α, BNP and Cys-C level is closely related to the cardiac function and the degree of renal injury in CHF patients. It can be used in clinical diagnosis and prognosis evaluation of CHF.

Key words： Chronic heart failure TNF-α BNP Cys-C

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	DAI Hongmei ZHU Yifang

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DAI Hongmei ZHU Yifang. Relationship between the level of serum TNF-α, BNP, Cys-C and heart-kidney function in patients with chronic heart failure[J]. 中国医药导报, 2019, 16(16): 155-158,162.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I16/155

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