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| Correlation between ultrasound tumor volume doubling time and breast cancer tumor proliferation/invasion molecule expression |
| HAN Yanfeng1 ZOU Shuwei2 WANG Baohua3▲ |
1.Department of Ultrasound, Taizhou Integrated Chinese and Western Medicine Hospital, Zhejiang Province, Taizhou 318000, China;
2.Department of Ultrasound, Wenling Women′s & Children′s Hospital, Zhejiang Province, Wenzhou 317500, China;
3.Department of Ultrasound, the First Affiliated Hospital of Zhejiang University, Zhejiang Province, Hangzhou 310006, China |
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Abstract Objective To investigate the relationship between ultrasound tumor volume doubling time (TVDT) and breast cancer tumor proliferation/invasion molecule expression. Methods From December 2016 to June 2018, 85 patients with breast cancer were selected from Taizhou Integrated Chinese and Western Medicine Hospital Zhejiang Province ("our hospital" for short). Another 56 patients in our hospital with breast adenoma diagnosed by pathology were selected. The patients were evaluated by three-dimensional ultrasound and TVDT was calculated. The pathological indexes of breast cancer and breast adenoma were analyzed statistically. Results The level of TVDT in breast cancer tumors was significantly lower than that in breast adenomas (P < 0.05), and the level of TVDT in patients with invasive ductal carcinoma was significantly lower than that in patients with ductal carcinoma in situ (P < 0.05). The proliferation-promoting genes, anti-proliferative genes, invasive genes, and anti-invasive genes were significantly different from the control group (P < 0.05). Pearson test showed that the level of TVDT in breast cancer was closely related to the expression of genes related to proliferation and invasion (|r| > 0.5, P < 0.05). Conclusion Abnormal TVDT levels may occur in patients with breast cancer, and the degree of reduction is closely related to the expression of genes involved in proliferation and invasion of breast cancer patients. Therefore, based on the level of TVDT, the therapeutic effect and prognosis of breast cancer patients can be evaluated.
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