土藤草汤治疗热毒壅盛、瘀浊内阻型急性痛风性关节炎的效果

Abstract
Figure/Table
References (31)
Related Citation (15)

Download: PDF (569 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To observe the clinical efficacy of Tutengcao Decoction in the treatment of acute gouty arthritis. Methods The clinical data of acute gouty arthritis patients with syndrome of exuberance of heat-toxin and blockade of static blood and turbidity treated in Department of Rheumatology, Dongfang Hospital Affiliated to Beijing University of Chinese Medicine from April 2013 to May 2017 was analyzed retrospectively. According to the therapeutic regimen, the patients were divided into Tutengcao Decoction group (120 cases), Colchicine group (63 cases) and Loxoprofen Sodium group (118 cases). Tutengcao Decoction group was given Tutengcao Decoction or Particles, one dose daily, taken orally in the morning and evening. Colchicine group was given Colchicine, 1 mg per time, 3 times a day. Loxoprofen Sodium group was given Loxoprofen Sodium, 60 mg per time, 3 times a day. The intervention time was 1 week. The relief time of joint symptoms, the improvement conditions of Chinese medicine symptoms and the improvement conditions of serum uric acid (sUA), C-reactive protein (CRP), erythrocyte sedimentation rate (ESR) before and after treatment among the three groups were observed. The clinical efficacy and safety of the three groups were compared. Results After 1 week of treatment, the relief time of joint pain and swelling in the Tutengcao Decoction group was shorter than those of the other two groups (P ＜ 0.01), the relief time of limitation of motion was significantly shorter than that of Loxoprofen Sodium group (P ＜ 0.01). In terms of Chinese medicine symptoms, the improvement rates of dry mouth and thirsty, dizziness, anorexia in Tutengcao Decoction group were significantly higher than those of the other two groups (P ＜ 0.05 or P ＜ 0.01), the improvement rate of constipation was higher than that of Loxoprofen Sodium group (P ＜ 0.01). Compared with those before treatment, the levels of sUA, CRP, ESR in the three groups were all significantly decreased after treatment (P ＜ 0.05). After treatment, the levels of CRP, ESR in Tutengcao Decoction group were significantly lower than those of the other two groups (P ＜ 0.05), the level of sUA was lower than that of Loxoprofen Sodium group (P ＜ 0.05). The effective rate of Tutengcao Decoction group was significantly higher than those of the other two groups (P ＜ 0.05). All three groups had no obvious adverse reactions. Conclusion In terms of improving clinical efficacy and decreasing the levels of sUA, Tutengcao Decoction is better than single Colchicine or Loxoprofen Sodium in the treatment of acute gouty arthritis.

Key words： Acute gouty arthritis Tutengcao Decoction Colchicine Loxoprofen Sodium Efficacy

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	ZHANG Honghong1 BU Xiangwei2 ZHANG Jianping2 WANG Kang3 ZHANG Chengcheng4 BAI Hua5 ZHANG Zhengju2 MENG Fengxian2

Cite this article:

ZHANG Honghong1 BU Xiangwei2 ZHANG Jianping2 WANG Kang3 ZHANG Chengcheng4 BAI Hua5 ZHANG Zhengju2 MENG Fengxian2. Efficacy of Tutengcao Decoction in the treatment of acute gouty arthritis with syndrome of exuberance of heat-toxin and blockade of static blood and turbidity[J]. 中国医药导报, 2019, 16(16): 116-119.

URL:

http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I16/116

[1] 卢芳，李慧.中医药治疗痛风的研究进展[J].中医药学报，2017，45（1）：103-106.
[2] 曾学军.2010年中国痛风临床诊治指南解读[J].中国实用内科杂志，2013，32（6）：438-441.
[3] 李鑫浩，赵树森.中医药治疗痛风性关节炎的研究进展[J].黑龙江医学，2014，38（11）：1235-1236.
[4] Neogi T，Jansen TL，Dalbeth N，et al. 2015 Gout classification criteria：An American College of Rheumatology/European League Against Rheumatism collaborative initiative [J]. Ann Rheum Dis，2015，74（10）：1789. doi：10.1136／annrheumdis-2015-208237.
[5] 中华人民共和国卫生部.中药新药临床研究指导原则[S].2002.
[6] 国家中医药管理局.22个专业95个病种中医诊疗方案[S].2010.
[7] Brikos C，O′Neill LA. Signaling of toll-like receptors [J]. Handb Exp Pharmacol，2008（183）：21-50.
[8] Krishnan J，Selvarajoo K，Tsuchiya M，et al. Toll-like receptor signal transduction [J]. Expland Mol Med，2007，39（4）：421-438.
[9] Sidiropoulos PI，Goulielmos G，Voloudarkis GK，et al. Inflammasomes and rheumatic diseases：evolving concepts [J]. Annrheum Dis，2008，67（10）：1382-1389.
[10] Joosten LA，Nea MG，Mylona E，et al. Enagagement of fatty acids with Toll-like receptor2 drives interleukin-1β production via the ASC/caspase1 pathway in monosodium ura monohydrate crystal-induced gouty arthritis [J]. Arthritis Rheum，2010，62（11）：3237-3248.
[11] 李明，黄传兵.中医药治疗痛风的临床研究进展[J].世界中西医结合杂志，2014，9（5）：347-350.
[12] 项婷，孙保国.尿酸方治疗湿瘀型高尿酸血症 51例[J].江西中医药，2014，8（8）：37-39.
[13] 钱玉中，李娜，苏于纳.高尿酸血症中医病名及病因病机的探讨[J].中医药导报，2013，19（1）：112-113.
[14] 张天星，王义军，贺娟.痛风的中医医理探究[J].中国中医基础医学杂志，2015，21（3）：268-269.
[15] 李沛，郭会卿.李振华治疗痛风经验[J].中医杂志，2010， 51（10）：875-876.
[16] 张白嘉，刘亚欧，刘榴，等.土茯苓及落新妇苷抗炎、镇痛、利尿作用研究[J].中药药理与临床，2004，20（1）：11-12.
[17] 中华人民共和国药典委员会.中华人民共和国药典[S].一部.北京：化学工业出版社，2005：14-15.
[18] Dolara P，Luceri C，Ghelardini C，et al. Analgestic effect of myrrh [J]. Nature，1996，379（6560）：29.
[19] 聂红，沈映君.白芷总挥发油对疼痛模型大鼠的β-内啡肽、促肾上腺皮质激素、一氧化氮及前阿黑皮素的影响[J].中国中药杂志，2002，27（9）：690-693.
[20] 聂红，沈映君.白芷挥发油对伤害性疼痛模型大鼠基因表达的影响[J].中药新药与临床药理，2003，14（1）：211.
[21] 陈志颜，陈于翠.土茯苓临床应用及作用机理研究现状[J].亚太传统医药，2014，10（1）：42-43.
[22] 胡家才，刘睿.黄柏对尿酸性肾病大鼠肾组织肿瘤坏死因子α及环氧化酶-2表达的影响[J].浙江中医药大学学报，2010，34（5）：655-657.
[23] 石玮，陶梦君，袁婷婷，等.金钱草单剂及合剂（山药）对高尿酸血症小鼠的影响[J].湖北科技学院学报：医学版，2017，31（2）：104-107.
[24] 姚譞，何枢衡，唐英.金钱草抗痛风活性组分的提取分离及药效筛选[J].中国现代中药，2014，16（12）：985-988，995.
[25] 鲁思爱.忍冬藤的化学成分及其药理应用研究进展[J].临沂大学学报，2012，34（3）：132-134.
[26] 张静.C反应蛋白的生物化学特征及临床应用究进展[J].中国医药指南，2013，11（16）：650-651.
[27] 朱柱华，谭毅.超敏C-反应蛋白在内科疾病中的应用研究进展[J].中国临床新医学，2012，5（12）：1198-1202.
[28] 陈祎，陆妍，孟凤仙，等.复方青秦液对尿酸性肾病大鼠肾组织Toll样受体表达的影响[J].中国中西医结合杂志，2014，34（6）：722-727.
[29] 商学征，马卫国，孟凤仙，等.复方青秦液对尿酸性肾病大鼠肾组织血管紧张素Ⅱ及环氧化酶-2影响的研究[J].中国中西医结合杂志，2014，34（7）：819-825.
[30] 孙晓龙，王宽宇，张丹琦.土茯苓注射液抗炎、镇痛作用的实验研究[J].中国中医药科技，2004，11（4）：231-232.
[31] 赵春苗，李亮亮.白芷总香豆素对疮疡模型的影响[J].中药药理与临床，2014，30（1）：61-63.