痰嗜酸粒细胞、25（OH）D3、FeNO检测在ACOS疾病诊断中的应用价值

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Abstract Objective To analyze the significance of induced sputum eosinophils, 25-hydroxyvitamin D [25 (OH) D3] and exhaled nitric oxide (FeNO) in the diagnosis of asthma-copd overlap syndrome (ACOS). Methods From January 2016 to May 2018, 50 patients diagnosed with ACOS in the First Hospital of Yulin City, Shaanxi Province were selected as the observation group and 50 patients with chronic obstructive pulmonary disease as the control group, the levels of phlegm eosinophils, 25(OH) D3 and FeNO in each group were analyzed, and ROC curves were drawn to analyze the diagnostic value of each index. Results The levels of eosinophil and 25 (OH) D3 in the observation group were lower than those in the control group (P ＜ 0.05), and FeNO level in the observation group was higher than that in the control group (P ＜ 0.05). The positive rates of eosinophil, 25 (OH) D3 and FeNO in the observation group were all higher than those in the control group, with statistically significant differences (P ＜ 0.05). In addition, the sensitivity of FeNO diagnosis was higher than 25 (OH) D3 (P ＜ 0.05), the specificity was higher than that of eosinophil (P ＜ 0.05), and the area under the ROC curve was higher than 25 (OH) D3 (P ＜ 0.05). Conclusion The use of phlegm eosinophils, 25 (OH) D3 and FeNO in the diagnosis of ACOS disease has a high application value, but the diagnostic value of FeNO is significantly higher than that of phlegm eosinophils and 25 (OH) D3.

Key words： Phlegm eosinophils 25- hydroxyvitamin D3 Exhaled nitric oxide Asthma-chronic obstructive pulmonary disease overlap syndrome

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	LI Li ZHAOJing▲

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LI Li ZHAOJing▲. Detection of induced sputum eosinophils, 25 (OH) D3 and FeNO in diagnosis of ACOS disease[J]. 中国医药导报, 2019, 16(16): 100-103.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I16/100

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