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| Serum levels of IL-33 and S1P in patients with bronchial asthma and their clinical significance |
| XU Huijuan SONG Mei LIN Zhaofan |
| Respiratory Department, the Second Affiliated Hospital of Shantou University Medical College, Guangdong Province, Shantou 515000, China |
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Abstract Objective To analyze the levels of interleukin 33 (IL-33) and 1- phosphosphingosine (S1P) in serum of patients with bronchial asthma and their clinical significance. Methods From September 2015 to May 2017, 83 patients with bronchial asthma admitted to the Second Affiliated Hospital of Shantou University School of Medicine ("our hospital" for short) were selected and divided into acute stage group (n = 48) and relief group (n = 35) according to the control of wheeze, 40 healthy subjects in our hospital in the same period were selected as the control group. Enzyme-linked immunosorbent assay (ELISA) was used to detect the levels of IL-33 and S1P in serum. Lung function measures, forced expiratory volume in the first second (FEV1), maximum peak expiratory flow rate (PEF), and forced expiratory volume/forced vital capacity in the first second (FEV1/FVC). Pearson correlation coefficient was used to analyze the correlation between serum IL-33 and S1P and pulmonary function indexes. Results Serum IL-33 and S1P levels in the acute stage group and the relief group were higher than those in the control group, and the levels in the acute stage group were also higher than those in the relief group, with statistically significant differences (all P ＜ 0.05). Lung function indexes FEV1, PEF and FEV1/FVC in the acute stage group and the relief group were all lower than those in the control group, while those in the acute stage group were also lower than those in the relief group, with statistically significant differences (all P ＜ 0.05). Pearson correlief coefficient analysis results showed that the serum IL-33 and S1P levels in the acute phase group and the remission group were negatively correlated with lung function indicators (r ＜ 0, P ＜ 0.05). Conclusion Serum IL-33 and S1P levels are significantly increased in patients with bronchial asthma, which is negatively correlated with lung function. The detection of serum IL-33 and S1P levels is helpful for the diagnosis of bronchial asthma.
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