CD4+CD25+调节性T细胞及转化生长因子-■1在血小板输注无效患者中的表达和意义

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Abstract Objective To investigate the expression and significance of CD4+CD25+ regulatory T cells and transforming growth factor-β1 (TGF-β1) in patients with platelet transfusion refractoriness (PTR). Methods Thirty-four patients with severe aplastic anemia (SAA) who had PTR from April 2017 to April 2018 in Guangzhou First People′s Hospital ("our hospital" for short) were selected as the study group. Another 44 SAA patients without PTR were selected as the control group. The expression levels of CD4+CD25+ regulatory T cells and plasma TGF-β1 were detected and compared in the two groups, and the diagnostic performance of the two indicators in PTR was analyzed by receiver operating curve (ROC). Results The expression levels of CD4+CD25+ regulatory T cells in the study group before and after infusion were lower than those in the control group (P < 0.05), and the plasma TGF-β1 level in the study group was lower than that in the control group (P < 0.05). According to ROC curve analysis, the area, sensitivity and specificity of CDT+CD25+ regulatory T cells and TGF-β1 combined detection and diagnosis of PTR were higher than those of the above two indicators (P < 0.05). Conclusion CD4+CD25+ regulatory T cells and TGF-β1 levels in PTR patients are significantly lower than those in control group. The expression of these two indicators can be detected in clinical work, which can provide reference for the prevention and treatment of PTR.

Key words： Platelet transfusion refractory CD4+CD25+ regulatory T cells Transforming growth factor-β1 Significance of expression

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	CHEN Xiaojie YUAN Zhaohu YANG Xuexin YANG Huikuan LUO Shulan

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CHEN Xiaojie YUAN Zhaohu YANG Xuexin YANG Huikuan LUO Shulan. Expression and significance of CD4+CD25+ regulatory T cells and transforming growth factor-β1 in patients with platelet transfusion refractoriness[J]. 中国医药导报, 2019, 16(16): 80-83.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I16/80

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