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| Predictive value of brain natriuretic peptide for paroxysmal atrial fibrillation after acute ischemic stroke |
| YUAN Mingjie1 BI Jihong2 |
1.Department of Cardiology, Renmin Hospital of Wuhan University, Hubei Province, Wuhan 430060, China;
2.Department of Clinical Pharmaceutics Room, Jinxiang People′s Hospital, Shandong Province, Jining 272200, China |
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Abstract Objective To investigate the predictive value of brain natriuretic peptide (BNP) for paroxysmal atrial fibrillation after acute ischemic stroke ("atrial fibrillation" for short). Methods A retrospective analysis of 130 patients with acute ischemic stroke admitted to Renmin Hospital of Wuhan University from October 2016 to June 2017 was performed. Patients were divided into atrial fibrillation group and sinus rhythm group according to whether there was atrial fibrillation or a history of atrial fibrillation at admission. The sinus rhythm group underwent 24-hour dynamic electrocardiogram monitoring for atrial fibrillation within 7 days after admission. Patients with sinus rhythm were divided into new atrial fibrillation group and non-atrial fibrillation group according to whether atrial fibrillation occurred during hospitalization. Plasma BNP levels were measured within 24 h after admission, and multivariate Logistic regression analysis was used to analyze the risk factors of new atrial fibrillation after acute ischemic stroke. Results A total of 130 patients with acute ischemic stroke were included in this study, including 80 patients with sinus rhythm and 50 patients with atrial fibrillation. Eighty patients with sinus rhythm underwent 24-hour dynamic electrocardiogram examination. Among them, 14 cases had new atrial fibrillation and 66 cases had no atrial fibrillation. Multivariate Logistic regression analysis showed that BNP was a risk factor for new atrial fibrillation after acute ischemic stroke (OR = 1.163, 95%CI: 1.042-1.297, P = 0.007). Conclusion BNP can predict the occurrence of paroxysmal atrial fibrillation after acute ischemic stroke.
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