氨基硫醇类辐射防护剂的研究进展

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Abstract With the development of nuclear technique, the threat of radiation exposure is increasing. As the first generation of radioprotectors, aminothiols can scavenge free radicals formed from ionizing radiation so that they can protect normal tissue from the harmful effects of ionizing radiation. Amifostine is the representative compound among aminothiols and the only small molecular radioprotective agent approved by FDA in clinical application at present, it has good radioprotective effects but many side effects such as hypotension. PrC-210 is a new aminothiol radioprotector, it has few side effects and high radioprotective efficacy. A better aminothiol radioprotectors can be obtained by controlling the number of amino groups in the molecular backbone and molecular weight, and modifying the sulfhydryl group in the molecule.

Key words： Ionizing radiation Radiation damage Radioprotectors Aminothiols Free radicals

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	LI Xuejiao TIAN Hongqi

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LI Xuejiao TIAN Hongqi. Research progress in radioprotectors from the family of aminothiols[J]. 中国医药导报, 2019, 16(16): 42-45.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I16/42

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