补阳还五汤对大鼠全脑缺血再灌注L型Ca2+通道平均开放时间的影响

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Abstract Objective To investigate the effect of Buyang Huanwu Decoction on the average opening time of L-type Ca2+ channel in rats with global cerebral ischemia-reperfusion. Methods Sixty-two rats with global cerebral ischemia-reperfusion were prepared by four-vessel occlusion method. They were divided into control group and research group by random number table method, with 31 rats in each group. The control group was fed with normal saline, while the research group was fed with Buyang Huanwu Decoction. After 2, 12, 24, 48 and 72 h of treatment, the rats were observed. The average opening time of L-type Ca2+ channel, brain water content, serum superoxide dismutase (SOD) and malondialdehyde (MDA) levels were compared between the two groups at different time points. Results The average opening time of L-type Ca2+ channels in the study group was significantly shorter than that in the control group (P < 0.05). Compared with 72 h after reperfusion, the average opening time of L-type Ca2+ channels in the two groups at different time points were statistically significant (P < 0.05). After ischemia-reperfusion treatment, the water content in the study group was also significantly lower than that in the control group (P < 0.05). Compared with 72 h after reperfusion, the brain water content in the other time points of the two groups were significant difference (P < 0.05). After intervention, serum SOD activity of the study group was higher than that of the control group and the MDA content was lower than that of the control group (P < 0.05). Conclusion Buyang Huanwu Decoction has a certain therapeutic effect on global cerebral ischemia-reperfusion injury in rats. Its effect is related to shortening the average opening time of L-type Ca2+ channel at different time points, decreasing the brain water content of rat, increasing the activity of serum SOD and decreasing the content of MAD in rat.

Key words： Buyang Huanwu Decoction Rat global cerebral ischemia Reperfusion L-type Ca2+ channel Pharmacodynamic study

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