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| Effect of Buyang Huanwu Decoction and Simiaosan on acute peripheral deep venous thrombosis of left lower extremity and its effect on D-dimer and hypersensitive C-reactive protein |
| HUO Jingshan HUANG Zijian HE You |
| Department of General Surgery, Foshan Hospital of Traditional Chinese Medicine, Guangdong Province, Foshan 528000, China |
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Abstract Objective To observe the changes of Buyang Huanwu Decoction and Simiaosan combined with urokinase on D-dimer (DD) and hypersensitive C-reactive protein (hs-CRP) in patients with acute peripheral deep venous thrombosis (DVT) of left lower extremity. Methods Sixty patients with acute left lower extremity DVT were enrolled in the study. They were randomly divided into study group (n = 30) and control group (n = 30). The study group was treated with traditional Chinese medicine (Buyang Huanwu Decoction combined with Simiaosan) and Western medicine (oral Rivaroxaban 14 days + intravenous urokinase 7 days), while the control group was treated with Western medicine (oral Rivaroxaban 14 days + intravenous urokinase 7 days). The levels of D-D and hs-CRP were measured before treatment and on the 1st, 4th, 7th, 11th and 14th days after treatment in both groups. The swelling, pain, color, circumference and tongue vein of the left lower limb before and after treatment were observed. Results The efficacy of TCM syndromes in the study group was significantly better than that in the control group, and the difference was statistically significant (P < 0.05). The D-D levels on the 4th, 7th, 11th and 14th day after treatment in the study group were lower than those in the control group, and the differences were highly statistically significant (P < 0.01). The hs-CRP levels in the study group were lower than those in the control group on the 1st, 4th, 7th, 11th and 14th day after treatment, and the differences were highly statistically significant (P < 0.01). Conclusion The clinical efficacy of Buyang Huanwu Decoction combined with Simiaosan combined with urokinase in the treatment of acute peripheral DVT of left lower extremity is better than that of Western medicine alone. Its mechanism may be related to the promotion of fibrinolysis system and the protection of vascular endothelial cells.
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