血清VEGF、ES水平与多囊卵巢综合征患者卵巢间质血流的关系

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Abstract Objective To investigate the relationship between serum vascular endothelial growth factor (VEGF), endostatin (ES) and ovarian stromal blood flow in patients with polycystic ovary syndrome (PCOS). Methods A total of 89 patients with PCOS admitted to Yongchuan District Traditional Chinese Medical Hospital of Chongqing City ("our hospital" for short) from January 2016 to December 2017 was recorded as PCOS group. According to insulin resistance index, PCOS group was divided into insulin resistance group (n = 47) and non-insulin resistance group (n = 42). Another 50 healthy women in the same period were selected as control group. Enzyme-linked immunosorbent assay (ELISA) was used to detect the level of VEGF and ES. The pulsatility index (PI), resistance index (RI) and peak velocity (PSV) was monitored by color Doppler ultrasound. Pearson test was used to analyze the correlation between VEGF, ES and ovarian stromal blood flow. Results The levels of VEGF, ES and PSV in PCOS group were higher than that control group, and PI and RI in PCOS group were lower than that in control group （P < 0.05）. The levels of VEGF, ES and PSV in insulin resistance group were higher than that in non-insulin resistance group, and PI and RI in insulin resistance group were lower than that in non-insulin resistance group （P < 0.05）. In PCOS patients, the levels of VEGF and ES were negatively correlated with PI and RI (rVEGF = -0.476, -0.491, rES = -0.423, -0.365, P < 0.05), and positively correlated with PSV (rVEGF = 0.504, rES = 0.463，P < 0.05). Conclusion The levels of VEGF and ES in PCOS patients are highly expressed, and increase with the increase of insulin resistance. Antiangiogenesis therapy is expected to become a new therapeutic target.

Key words： Polycystic ovary syndrome Vascular endothelial growth factor Endostatin Ovarian stromal blood flow

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	JIANG Xuexia YIN Daoying LI Xiaoling YANG Yan WANG Bowei

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JIANG Xuexia YIN Daoying LI Xiaoling YANG Yan WANG Bowei. The relationship between serum VEGF and ES level and ovarian stromal blood flow in patients with polycystic ovary syndrome[J]. 中国医药导报, 2019, 16(15): 84-87,99.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I15/84

[1] 袁源.子宫内膜异位症患者血清IGF-1和VEGF表达及与疾病严重程度的关系[J].中国妇幼保健，2016，31（22）：4678-4680.
[2] Gonzálezpalomares B，Coronado Martín PJ，Maestro de Las Casas ML，et al. Vascular endothelial growth factor（VEGF）polymorphisms and serum VEGF levels in women with epithelial ovarian cancer，benign tumors，and healthy ovaries [J]. Int J Gynecol Cancer，2017，27（6）：1088-1095.
[3] 李琼，薛晓红，江科，等.乳腺癌患者血清与肿瘤组织中VEGF、ES表达和微血管密度的关系[J].世界中西医结合杂志，2016，11（12）：1676-1678.
[4] 金纬纬，蔡平生，方轶萍，等.多囊卵巢综合征患者子宫内膜HIF-1α表达及与子宫内膜容受性的关系[J].浙江中西医结合杂志，2016，26（7）：612-614.
[5] 刘梅梅，李佩玲，尹晓静，等.血管生成相关因子内皮抑素和血小板反应素-1在多囊卵巢综合征大鼠卵巢组织中的表达及意义[J].疑难病杂志，2016，15（11）：1178-1181，1186，1211.
[6] 杨昱，刘超.2013年美国内分泌学会多囊卵巢综合征诊疗指南解读[J].中华内分泌代谢杂志，2014，30（2）：89-92.
[7] 陈艳，章慧君.多囊卵巢综合征中医证型与其超声形态学、血流学的相关性分析[J].新中医，2016，28（9）：101-102.
[8] 钟慧，刘敏，刘利英，等.消癌平片辅助化疗治疗晚期子宫内膜癌[J].国际中医中药杂志，2018，40（12）：1129-1133.
[9] Rahimi Z，Chamaie-Nejad F，Saeidi S，et al. The association of PPARγPro12Ala and C161T polymorphisms with polycystic ovary syndrome and their influence on lipid and lipoprotein profiles [J]. Int J Fertil Steril，2018，12（2）：147-151.
[10] 刘梅梅，丁慧，尹晓静，等.多囊卵巢综合征患者血清血管内皮生长因子、内皮抑素水平及对卵巢间质血流的影响研究[J].中国全科医学，2017，20（4）：448-453.
[11] Wu MH，Huang MF，Tsai SJ，et al. Short term effects of laparoscopic ovarian drilling in clomiphene citrate resistant patients with polycystic ovary syndrome [J]. J Am Assoc Gynecol Laparosc，2004，11（2）：184-190.
[12] 胡晓玲，周青，彭朝龙，等.多囊卵巢综合征卵巢组织与血清中VEGF、ES及MVD的表达与意义[J].同济大学学报：医学版，2011，32（4）：40-42.
[13] Salem AB，Megdich F，Kacem O，et al. Vascular endothelial growth factor（VEGFA）gene variation in polycystic ovary syndrome in a Tunisian women population [J]. BMC Genomics，2016，17（9）：748-757.
[14] 寇燕妮，马晓梅，冯春香.多囊卵巢综合征不同临床表现患者超声参数与内分泌指标特征分析[J].临床医学工程，2017，24（11）：1501-1502.
[15] 张雅洁.sRAGE、VEGF在多囊卵巢综合征患者血清和卵泡液中的表达及相关性分析[D].郑州：郑州大学，2015.
[16] Elci E，Kaya C，Cim N，et al. Evaluation of cardiac risk marker levels in obese and non-obese patients with polycystic ovaries [J]. Gynecol Endocrinol，2016，33（1）：1-10.
[17] 张真，廖清池，柳书可，等.微小RNA与血管内皮细胞的衰老关系研究进展[J].中华老年心脑血管病杂志，2018， 20（12）：1327-1329.
[18] 左莉，傅亚均.多囊卵巢综合征病因及治疗进展[J].重庆医学，2018，47（9）：1247-1250.
[19] 史晓明，祁秀娟，吕映频，等.多囊卵巢综合征患者血清VEGF及PEDF与卵巢过度刺激综合征的关系[J].现代妇产科进展，2015，24（5）：360-362.
[20] 张文杰，蒋小芒，冯卫红.多囊卵巢综合征患者妊娠早期血清抵抗素水平对妊娠并发症及不良妊娠结局的影响[J].临床和实验医学杂志，2018，17（24）：2656-2658.
[21] 袁浩，牛志宏.多囊卵巢综合征合并代谢综合征患者卵巢颗粒细胞瘦素启动子甲基化的研究[J].上海交通大学学报：医学版，2018，38（11）：1312-1317.