股骨颈骨折患者氧化应激对骨折愈合进度和凝血功能的影响

Abstract
Figure/Table
References (23)
Related Citation (15)

Download: PDF (512 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To study the effect of oxidative stress on fracture healing process and coagulation function in patients with transcervical fracture (TF). Methods A total of 118 patients with TF who underwent surgery in Jianghan Oilfield General Hospital of Hubei (“our hospital” for short) from January 2014 to March 2018 was selected as the observation group. Another 120 volunteers who received a physical examination in our hospital during the same period were selected as the control group. The observation group was followed up for 4 months after surgery. The oxidative stress index, coagulation function and coagulation function of patients with different fracture healing progress were detected and compared between the two groups, and the correlation between the indexes was analyzed. Results The total antioxidant capacity (TAC), catalase (CAT) and superoxide dismutase (SOD) levels in the observation group were significantly lower than those in the control group, and the malondialdehyde (MDA) level was significantly higher than that in the control group (P < 0.05). There were no significant differences in prothrombin time, activated partial thromboplastin time and thrombin time between the two groups (P > 0.05). The level of fibrinogen (FIB) in the observation group was significantly higher than that in the control group (P < 0.05). The levels of TAC, CAT and SOD in the 3-month healing group were significantly higher than those in the 4-month healing group and the delayed healing group. The MDA and FIB levels were significantly lower than those in the 4-month healing group and the delayed healing group (P < 0.05). The levels of TAC, CAT and SOD in the 4-month healing group were significantly higher than those in the delayed healing group, and the MDA and FIB levels were significantly lower than those in the delayed healing group (P < 0.05). The TAC, CAT and SOD levels of TF patients were negatively correlated with fracture healing progress and FIB, respectively. MDA was positively correlated with fracture healing progress and FIB (P < 0.05). Conclusion Oxidative stress in TF patients may have certain effects on the progress of fracture healing and coagulation function. It is possible to comprehensively monitor the oxidative stress index of patients, which can help to judge the prognosis of rehabilitation. It is worthy of attention.

Key words： Transcervical fracture Oxidative stress Progress of fracture healing Coagulation function

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	MING Liang1 WANG Aibing1 LIU Sheng1 LI Kunqing1 LUO Zhengqiang2

Cite this article:

MING Liang1 WANG Aibing1 LIU Sheng1 LI Kunqing1 LUO Zhengqiang2. Effects of oxidative stress on fracture healing progress and coagulation function in patients with transcervical fracture[J]. 中国医药导报, 2019, 16(15): 65-68,76.

URL:

http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I15/65

[1] 李学智.全髋与半髋关节置换术治疗老年人股骨颈骨折效果分析与研究[J].心理医生，2018，24（4）：130-131.
[2] 刘明巍，张寅龙，贾世孔，等.利伐沙班与低分子肝素防治高龄股骨颈骨折围术期深静脉血栓效果对比[J].中国老年学杂志，2016，36（14）：3545-3546.
[3] 唐远毅.自拟强骨活血方配合闭合复位空心钉内固定术治疗青壮年股骨颈骨折疗效观察[J].现代中西医结合杂志，2018，27（16）：1781-1784.
[4] 黄伟，许力月，邵森垚，等.髋部骨折对老年患者凝血功能的影响[J].北京大学学报：医学版，2013，45（5）：742-744.
[5] 邱贵兴，裴福兴，胡侦明，等.中国骨质疏松性骨折诊疗指南[J].中华骨与关节外科杂志，2015，8（5）：371-374.
[6] 方超华，何志勇，章军辉，等.股骨颈骨折预防性抗凝致肝素诱导性血小板减少症1例报道[J].中华骨与关节外科杂志，2018，11（3）：216-218.
[7] Vk K，Ss B，Mm D，et al. Single Stage Treatment of Non-Union of Transcervical Neck Femur Fracture with Shepherd Crook Deformity of Proximal Femur in A Case of Fibrous Dysplasia using Dynamic Hip Screw Fixation [J]. J Orthop Case Rep，2015，5（3）：41-44.
[8] 何明章.高龄股骨颈骨折患者人工全髋关节置换术后下肢深静脉血栓形成Logistic回归分析[J].中国保健营养，2016，26（1）：261-262.
[9] 陈尊荣，徐献信.C臂引导经皮空心螺钉内固定治疗对股骨颈骨折患者骨代谢及机体应激的影响观察[J].中国医药科学，2016，6（12）：189-192.
[10] 容向宾，陈跃平，夏天.创伤性骨折患者氧化应激指标变化及中医治疗效果研究[J].解放军预防医学杂志，2018， 36（2）：198-200，270.
[11] 常庆华.骨折患者不同应激水平对凝血功能、血小板参数及深静脉血栓形成的影响[J].当代医学，2018，24（11）：15-17.
[12] 叶志扬，简国坚，王俊，等.髋关节置换术中应用骨水泥对患者凝血功能变化与术后关节功能的影响[J].河北医药，2018，40（19）：2922-2925.
[13] 彭城，王晓伟，李绍光，等.老年患者不同部位的髋部骨折对预后的影响[J].中国骨伤，2017，30（10）：906-910.
[14] Mei J，Liu S，Jia G，et al. Finite element analysis of the effect of cannulated screw placement and drilling frequency on femoral neck fracture fixation [J]. Injury，2014， 45（12）：2045-2050.
[15] 冯文龙，周炳华，黄伟，等.股骨颈骨折患者氧化应激水平与骨折愈合进度和凝血功能的相关性研究[J].创伤外科杂志，2018，20（7）：544-546.
[16] 周芳.中医综合护理老年股骨颈骨折术后下肢深静脉血栓形成随机平行对照研究[J].实用中医内科杂志，2014， 28（9）：147-149.
[17] 陆荣，张文清，顾始伟，等.比较腰硬联合麻醉与静吸复合麻醉对股骨颈骨折行人工股骨头置换后血栓弹力图的影响[J].中华临床医师杂志：电子版，2012，6（8）：2232-2233.
[18] 张岩，周正楠，张子韬，等.创伤患者血浆D-二聚体、纤维蛋白原与骨折部位及创伤程度的相关性研究[J].实用骨科杂志，2016，22（8）：706-710.
[19] 李灿辉，吴征杰.益气活血化瘀法干预老年股骨干骨折患者术后高凝状态临床研究[J].安徽中医药大学学报，2017，36（3）：25-28.
[20] 朱岩，王传福.比较腰硬联合麻醉与静吸复合麻醉对股骨颈骨折行人工股骨头置换后血栓弹力图的影响[J].系统医学，2017，2（1）：55-57.
[21] 宋建康.髋关节置换术与骨折内固定术对老年股骨颈骨折患者的疗效及Harris评分的影响[J].中国医药科学，2017，7（17）：223-226.
[22] 王创明，郑洵，陈海波，等.股骨颈骨折人工股骨头置换围术期红细胞沉降率和血清炎症因子含量的变化及其临床意义[J].中国医药导报，2017，14（18）：98-101.
[23] Gupta S，Kukreja S，Singh V，et al. Valgus osteotomy and repositioning and fixation with a dynamic hip screw and a 135 single-angled barrel plate for un-united and neglected femoral neck fractures [J]. J Orthop Surg （Hong Kong），2014，22（1）：13-17.