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| Research progress on multidrug resistance in leukemia and regulation of PTEN |
| LIN Nan LYU Peng ZHAO Huan WU Chaoxu WANG Yin ZENG Zhihao HOU Li ZHANG Yayue |
| Department of Hematology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China |
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Abstract Reversing multidrug resistance in leukemia is challenging. Studies have shown that PTEN gene is a tumor suppressor gene with protein phosphatase and lipid phosphatase activities. PTEN gene participates in cell growth, differentiation and proliferation through various signalling pathways and leukemia stem cells (LSCs) show mutation, deletion or reduction in expression of the PTEN gene. As such, PTEN gene is a potential target for clearing LSCs and reversing multidrug resistance in leukemia. This paper analyzes the regulatory activity of PTEN gene on cell growth, differentiation and proliferation through inhibiting the MAPK, FAK/P130cas and PI3K/AKt/mToR signalling pathways, also reviews the recent advancements in the research on the role of PTEN gene in multidrug resistance in leukemia.
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