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| Research progress of novel APJ ligand peptide hormone Elabela in cardiovascular system |
| HUANG Sihui TANG Qizhu▲ |
| Department of Cardiology, Renmin Hospital of Wuhan University, Cardiovascular Research Institute of Wuhan University, Hubei Key Laboratory of Cardiology, Hubei Province,Wuhan 430060, China |
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Abstract Elabela is a new type of endogenous angiotensin receptor AT1-related receptor protein (APJ) ligand, which was believed to be mainly expressed in embryonic tissues in early studies, but recent studies have found that as an endogenous hormone, Elabela is also expressed in tissues and organs such as heart and blood vessels after embryonic development. APJ plays a regulatory role in the cardiovascular system of mammals, and Elabela, as one of the APJ ligands, also plays an important role in the cardiovascular system. This paper mainly discusses the role of Elabela in cardiovascular development and cardiovascular diseases and its clinical application prospect.
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