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| Effects of different doses of Dexmedetomidine on stress response and cytokines level in patients underwent gynecological laparoscopic surgery |
| SHI Jianwen |
| Anesthesiology Department of Obstetrics and Gynecology, Women and Children's Hospital of Qingdao City, Shandong Province, Qingdao 266034, China |
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Abstract Objective To explore the effect of different doses of Dexmedetomidine in gynecological laparoscopic operation and the influence on stress response and cytokines. Methods 80 cases of patients underwent gynecological laparoscopic operation in Women and Children's Hospital of Qingdao City from February 2014 to February 2016 were selected. According to the doses of Dexmetrine before anesthesia, patients were divided into two groups, each groups had 40 cases. Patients in the control group were treated with a moderate doses of Sufentanil, Rocuonium Bromide and Propofol. 0.2 μg/kg Dexmedetomidine was given 10 min before anesthesia induction, maintained by 0.5 μg/(kg·h) until 30 min before the end of the surgery. Patients in the study group were given 0.5 μg/kg Dexmedetomidine at 10 min before anesthesia induction, maintained by 1 μg/(kg·h) until 30 min before the end of the surgery. The HR, MAP and levels of TNF-α, IL-6 and IL-10 were detected at 10 min before anesthesia induction (T1), 1 min after tracheal intubation (T2), 1 min after pneumoperitoneum (T3) and the end of the operation (T4). Results At T2-T4, the MAP levels of the study group were lower than those of the control group, at T2-T3 the HR levels of the study group were lower than those of the control group, with statistically significant differences (P < 0.05). The results of inflammatory cytokine comparison within groups showed that compared with T1, at T2-T4 the levels of TNF-α, IL-6 and IL-10 significantly increased in the two groups (P < 0.05); the results of comparison among groups showed that at T1 there were no statistically significant differences in TNF-α, IL-6 and IL-10 levels between the two groups (P > 0.05), compared with the control group, at T2-T4 the levels of TNF-α and IL-6 significantly decreased and IL-10 levels significantly increased in the study group (P < 0.05). Conclusion The application of 0.5 μg/kg Dexmedetomidine in gynecological laparoscopic operation can reduce inflammatory cytokine levels, decrease inflammatory response, which is conducive to the operation and has great effects.
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