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| Clinical effect of Diazepam combined with Phenobarbital in the treatment of infantile convulsion |
| HUANG Jing1 DENG Jing2▲ |
1.Department of Paediatrics, Jiangjin Chinese Medicine Hospital of Chongqing City, Chongqing 402260, China;
2.Department of Paediatrics, Jiangjin Maternal and Child Health Hospital of Chongqing City, Chongqing 402260, China |
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Abstract Objective To analyze the effect of Diazepam combined with Phenobarbital in the treatment of infantile convulsion and the influence of serological indicators on children. Methods 91 cases with febrile convulsion treated in Jiangjin Chinese Medicine Hospital of Chongqing City from March 2013 to April 2015 were divided into control group and observation group according to the random number table. The control group was treated with Diazepam drugs administered as intravenous note. The observation group was treated with Phenobarbital based on control group. Clinical efficacy, serum parameters, prognosis and immune function of two groups were evaluated. Results Total efficacy rate of observation group was significantly higher than that of control group, the difference was statistically significant (P < 0.05). The cumulative recurrence rates at 6, 12 months in control group were significantly higher than those in observation group, the differences were statistically significant (P < 0.05). The number of patients transferinto epilepsy at 6, 12 months in control group were significantly higher than those in observation group, the differences were statistically significant (P < 0.05). After treatment, the serum level of NSE, S-100 beta, BNDF in observation group were significantly lower than those in control group, the differences were statistically significant (P < 0.05). After treatment, IgA, IgM and IgG levels in observation group were significantly lower than those in control group, the differences were statistically significant (P < 0.05). After treatment, the proportion of CD4+ in observation group was significantly higher than that in control group (P < 0.05), the proportion of CD8+ in observation group was significantly lower than that in control group (P < 0.05), the ratio value of CD4+/CD8+ in observation group was significantly higher than that in control group (P < 0.05). Conclusion The effect of Diazepam combined with Phenobarbital in the treatment of infantile convulsion is exact, can reduce serum NSE, S-100β, BNDF levels, has a good clinical application prospects.
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