|
|
|
| Change of interleukin-17 levels in both synovial fluid and serum of patients with medial compartment knee osteoarthritis after proximal fibular osteotomy |
| BAI Yuming1 ZHANG Haisen1 LIU Chang1 JIN Shengli1 WANG Wenjie2 LIU Ying3 ZHANG Yanping3 LYU Zhichang4 |
1.The Second Department of Orthopaedics, Cangzhou Central Hospital, Hebei Province, Cangzhou 061001, China;
2.Emergency Drpartment, Cangzhou Central Hospital, Hebei Province, Cangzhou 061001, China;
3.Operating Room, Cangzhou People′s Hospital, Hebei Province, Cangzhou 061001, China;
4.Department of Orthopaedics, People′s Hospital of Xian County, Hebei Province, Xian County 062250, China |
|
|
|
Abstract Objective To investigate interleukin-17 (IL-17) levels in both synovial fluid and serum of patients with medial compartment knee osteoarthritis (KOA) after proximal fibular osteotomy. Methods Thirty patients with medial compartment KOA underwent proximal fibular osteotomy at the Cangzhou Central Hospital from December 2014 to June 2015 were selected as experimental group, and 30 healthy individuals were selected as control group into the study. Visual analog pain score (VAS) and Knee Society score (KSS) were used to evaluate pain level and function of the experimental group. The IL-17 levels in both serum and synovial fluid of the experimental group at preoperative period and postoperative 6, 12, 18 months were measured by ELISA, also the serum levels of IL-17 in the control group were measured by ELISA. Results All incisions were healed in phase I. And all patients were followed up at least 18 months. The average tibiofemoral angle was (168.6±3.4)° at 18 months after surgery. Average postoperative VAS pain and KSS scores were significantly improved compared with preoperative period (P < 0.05), while there were no statistically significant differences during postoperative points (P > 0.05).The serum levels of IL-17 in the experimental group at different time points were higher than that in the control group (P < 0.05). The IL-17 levels in both serum and synovial fluid of the experimental group during postoperative points were decreased compared with preoperative period (P < 0.05), while there were no statistically significant differences during postoperative points (P > 0.05). Conclusion Proximal fibular osteotomy can significantly improve the pain symptoms and joint function of the patients with medial compartment KOA. It also can reduce the IL-17 levels in both synovial fluid and serum, while which can not back to healthy level.
|
|
|
|
|
|
[1] Cooper BG，Stewart RC，Burstein D，et al. A tissue-penetrating double network restores the mechanical properties of degenerated articular cartilage [J]. Angew Chem Int Ed Engl，2016，55（13）：4226-4230.
[2] Honsawek S，Deepaisarnsakul B，Tanavalee A，et al. Association of the IL-6 -174G/C gene polymorphism with knee osteoarthritis in a Thai population [J]. Genet MolRes，2011，10（3）：1674-1680.
[3] Hulin-Curtis SL，Bidwell JL，Perry MJ. Evaluation of IL18 and IL18R1 polymorphisms：genetic susceptibility to knee osteoarthritis [J]. Int J Immunogenet，2012，39（2）：106-109.
[4] 张海森，白玉明，靳胜利，等.白细胞介素-17基因多态性与骨关节炎易感性之间的相关性研究[J].中华骨科杂志，2016，36（22）：1450-1455.
[5] 张海森，白玉明，刘畅，等. 血清及滑液白介素-17水平与膝骨关节炎退变及膝痛程度的相关性研究[J].中国医药导报，2016，13（33）：84-87.
[6] Kan JI，Mishima S，Kashiwakura JI，et al. Interleukin-17A expression in human synovial mast cells in rheumatoid arthritis and osteoarthritis [J]. Allergol Int，2016，65 Suppl：S11-S16.
[7] Cho SD，Youm YS，Kim JH，et al. Patterns and influencing factors of medial meniscus tears in varus knee osteoarthritis [J]. Knee Surg Relat Res，2016，28（2）：142.
[8] Vandekerckhove PT，Matlovich N，Teeter MG，et al. The relationship between constitutional alignment and varus osteoarthritis of the knee [J]. Knee Surg Sports Traumatol Arthrosc，2016：1-7.
[9] Haraguchi N，Ota K，Tsunoda N，et al. Weight-bearing-line analysis in supramalleolar osteotomy for varus-type osteoarthritis of the ankle[J]. J Bone Joint Surg Am，2015，97（4）：333-339.
[10] 张英泽，李存祥，李冀东，等.不均匀沉降在膝关节退变及内翻过程中机制的研究[J].河北医科大学学报，2014， 35（2）：218-219.
[11] 董天华，李石伦，于沂阳，等.不均匀沉降理论新进展[J].河北医科大学学报，2016，37（11）：1354.
[12] 陈伟，秦迪，吴涛，等.应用腓骨截骨术治疗膝关节骨性关节炎效果优良的机制分析[J].河北医科大学学报，2015， 36（6）：726-727.
[13] Oudenaarde KV，Jobke B，Oostveen ACM，et al. Predictive value of MRI features for development of radiographic osteoarthritis in a cohort of participants with pre-radiographic knee osteoarthritis-the CHECK study [J]. Rheumatology，2017，56（1）： 113-120.
[14] Altman RD. Criteria for the classification of osteoarthritis of the knee and hip [J]. Scand J Rheumatol Suppl，1987，65（Supp 65）：31-39.
[15] Silva ALPE，Demange MK，Gobbi RG，et al. Translation and Validation of the Knee Society Score-KSS for Brazilian Portuguese [J]. Acta Ortopédica Brasileira，2012， 20（1）：25-30.
[16] Karabis A，Nikolakopoulos S，Pandhi S，et al. High correlation of VAS pain scores after 2 and 6 weeks of treatment with VAS pain scores at 12 weeks in randomised controlled trials in rheumatoid arthritis and osteoarthritis： meta-analysis and implications [J]. Arthritis Res Ther，2016，18（1）：1-7.
[17] 余黄合，魏艳霞，林也，等. IL-23/IL-17炎症轴在类风湿关节炎发病机制中的研究进展[J].中国医药导报，2016，13（31）：37-41.
[18] Wu X，Kondragunta V，Kornman KS，et al. IL-1 receptor antagonist gene as a predictive biomarker of progression of knee osteoarthritis in a population cohort[J]. Osteoarthritis Cartilage，2013，21（7）：930-938.
[19] Chen L，Li DQ，Zhong J，et al. IL-17RA aptamer-mediated repression of IL-6 inhibits synovium inflammation in a murine model of osteoarthritis [J]. Osteoarthritis Cartilage，2011，19（6）：711-718.
[20] Wang K，Xu J，Cai J，et al. Serum levels of interleukin-17 and adiponectin are associated with infrapatellar fat pad volume and signal intensity alteration in patients with knee osteoarthritis[J]. Arthritis Res Ther，2016，18（1）：193.
[21] Deligne C，Casulli S，Pigenet A，et al. Differential expression of interleukin-17 and interleukin-22 in inflamed and non-inflamed synovium from osteoarthritis patients[J]. Osteoarthritis Cartilage，2015，23（11）：1843-1852.
[22] Wang K，Xu J，Cai J，et al. Serum levels of resistin and interleukin-17 are associated with increased cartilage defects and bone marrow lesions in patients with knee osteoarthritis [J]. Mod Rheumatol，2017，27（2）：339-344.
[23] 周磊，曲铁兵，林源，等.腓骨近端截骨术治疗膝关节骨关节炎的疗效评价[J].中华老年骨科与康复电子杂志，2016，2（1）：16-20.
[24] 佟刚，解强.膝关节镜结合腓骨近端截骨术对膝关节内侧间室骨关节炎的疗效[J].中华医学杂志，2016，96（43）：3508-3510. |
|
|
|
