|
|
Effect of iliac bone flap pedicled with deep circumflex iliac artery with decalcified human dental matrix material in the treatment of osteonecrosis of the femeral head |
ZHANG Leming FENG Jianshu▲ FU Qiang WANG Jiangyong |
Department of Orthopedics, Shijiazhuang the Third Hospital, Hebei Province, Shijiazhuang 050011, China |
|
|
Abstract Objective To investigate the effect of iliac bone flap pedicled with deep circumflex iliac artery with decalcified human dental matrix material (DTM) in the treatment of osteonecrosis of the femeral head. Methods From September 2013 to October 2015, 166 patients with osteonecrosis of the femeral head from the Department of Orthopedics, Shijiazhuang the Third Hospital were selected and divided into control group and experiment group, with 83 cases in each group. The control group was treated with implantation of iliac bone flap pedicled with deep circumflex iliac artery, while the experiment group was received implantation of iliac bone flap pedicled with deep circumflex iliac artery with DTM, hip symptoms and functional score, serum osteocalcin (BGP), type Ⅰ procollagen N propeptide (PINP), type Ⅰ procollagen C terminal peptide (CTX-Ⅰ) levels, SF-36 quality of life score were compared. Results Compared with the control group, pain visual analogue scale (VAS) score in the experiment group was lower, Japanese Society of Department of orthopedics (JOA) hip function score and Harris hip score in the experiment group were higher after treatment, serum levels of BGP、PINP、CTX-Ⅰ were lower, phyisical component summary scale (PCS) and mental component summary scale (MCS) score in the SF-36 quality of life were higher, with significant difference (P < 0.05). Conclusion The clinical curative effect of iliac bone flap pedicled with deep circumflex iliac artery with DTM in the treatment of osteonecrosis of the femeral head is exactly, which can reduce the levels of serum BGP, PINP, CTX-Ⅰ and hip pain symptoms, improve the function of hip joint and life quality of the patients.
|
|
|
|
|
[1] Powell C,Chang C,Gershwin ME. Current Concepts on the Pathogenesis and Natural History of Steroid-Induced Osteonecrosis [J]. Clin Rev Allergy Immunol,2011,41(1):102-113.
[2] 景鹏举,王勇平,王建民.成人股骨头坏死的诊治现状[J].现代医药卫生,2016,32(24):3805-3808.
[3] 王元,王建忠.非创伤性股骨头坏死基因多态性的研究进展[J].中国现代医生,2015,53(26):157-160.
[4] 周磊,翁习生.激素性股骨头坏死动物模型的选择与应用[J].中国矫形外科杂志,2013,21(21):2155-2158.
[5] 于志亮,张宁,王斌,等.带旋髂深血管蒂髂骨瓣植入治疗成人股骨头缺血性坏死[J].中国综合临床,2013,29(3):303-305.
[6] 张志勇,朱兴元,田顺林,等.骨诱导成骨材料在骨修复治疗中的临床疗效观察[J].实用骨科杂志,2012,18(10):947-948.
[7] 中华医学会骨科分会显微修复学组.成人股骨头坏死诊疗标准专家共识(2012年版)[J].中华骨科杂志,2012,32(6):51-56.
[8] Gardeniers JWM. A new international classification of osteonecrosis of the ARCO committee on terminology and classification [J]. J Jpn Orthop Assoc,1992,66(2):18-19.
[9] 齐海,丁悦,许杰,等. Harris评分和X线在评价全髋关节置换术后疗效中的作用[J].中华关节外科杂志电子版,2009,3(4):24-26.
[10] 孙兵,车晓明.日本骨科协会评估治疗(JOA评分)[J].中华神经外科杂志,2012,28(6):623.
[11] 王素华,李立明,李俊. SF-36健康调查量表的应用[J].中国社会医学杂志,2001,18(1):4-8.
[12] 成鲁杰,李健.综合疗法治疗早期股骨头坏死临床研究[J].实用中医药杂志,2017,33(1):5-6.
[13] 宋奕,丁道芳,李玲慧,等.细胞凋亡在激素性股骨头坏死机制中的研究进展[J].中国矫形外科杂志,2013,21(21):2163-2165.
[14] 樊天,余方圆,温振涛,等.非创伤性股骨头坏死的机制及早期治疗的研究进展[J].现代生物医学进展,2016, 16(21):4170-4173.
[15] 马勇,马喜洪.股骨头坏死病因、发病机制及治疗研究进展[J].医学综述,2015,21(9):1574-1576.
[16] 尹晓光.带血管蒂髂骨瓣植入治疗成人股骨头坏死临床效果观察[J].世界最新医学信息文摘:连续型电子期刊,2016,17(71):84.
[17] 于志亮,张宁,杨义,等.带旋髂深血管蒂髂骨瓣及松质骨移植治疗青壮年股骨颈骨折术后股骨头缺血性坏死[J].中国综合临床,2015,31(1):83-87.
[18] 范小波,李高强,段泽敏.骨诱导成骨材料在骨修复治疗中的临床疗效观察[J].医药论坛杂志,2013,33(11):947-948.
[19] 孙云明.髓芯减压联合干细胞移植对股骨头坏死患者血清PINP、CTX、OST水平的影响[J].中国老年学杂志,2015, 35(14):3972-3973.
[20] Rackwitz L,Eden L,Reppenhagen S,et al. Stem cell-and growth factor-based regenerative therapies for avascular necrosis of the femoral head [J]. Stem Cell Res Ther,2012,3(1):7. |
|
|
|