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| The effect and mechanism of extract of Folium Ginkgo in protecting the early renal injury caused by extracorporeal shock wave lithotripsy |
| ZHAO Junlong1 JIANG Ning2 LI Yan1 XU Jidong2 ZHANG He2 HU Chuanyi2▲ |
1.Ningxia Medical University, Ningxia Hui Autonomous Region, Yinchuan 750004, China;
2.Department of Urology Surgery, Shanghai Pudong New Area Gongli Hospital, Shanghai 200135, China |
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Abstract Objective To study the protective effect of extract of Folium Ginkgo in the early renal injury caused by extracorporeal shock wave lithotripsy (ESWL), and to explore it possible mechanism. Methods Eighty patients with unilateral lithotripsy pelvis/calyceal calculi underwent ESWL admitted to Shanghai Pudong New Area Gongli Hospital from January 2016 to January 2017 were randomly divided into observation group and control group, with 40 cases in each group. The observation group was administrated with Folium Ginkgo 20 mL plus normal saline 250 mL, 3 d before ESWL, intravenous drip, q12h, 5 d; the control group was administrated with normal saline 250 mL at the same time point. The differences of renal injury [urine neutrophil gelatinase-associated lipocalin (NGAL), cystatin C (Cys-C)] and the levels of serum oxygen radical [malondialdehyde (MDA), myeloperoxidase (MPO)], antioxidation [total antioxidant capacity (TAC), total superoxide dismutase (TSOD)] before and after lithotripsy in the two groups were compared. Results 24 h after ESWL, the levels of urine NGAL and urine Cys-C in observation group [(17.56±3.94), (38.29±3.84) ng/mL] were lower than those of control group [(22.68±4.82), (45.63±5.37) ng/mL], the differences were highly statistically significant (P ＜ 0.01); the levels of serum MDA and MPO [(5.05±0.84) mmol/L, (68.64±21.35) U/mg] were lower than those of control group [(5.91±1.13) mmol/L, (76.28±22.17) U/mg], the differences were statistically significant (P ＜ 0.05); the levels of serum TSOD and TAC [(147.65±43.38) kU/L, (12.58±3.34) U/mg] were higher than those of control group [(123.52±41.29) kU/L, (8.35±2.14) U/mg], the differences were also statistically significant (P ＜ 0.05, P ＜ 0.01). Conclusion The extract of Folium Ginkgo can effectively protect the renal injury caused by ESWL, the mechanism may be through enhancing the antioxidation ability and eliminating oxygen free radicals.
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