|
|
|
| Analysis on the clinical related influence factors of thyroid stimulating hormone in the early pregnancy of pregnant women |
| JIANG Qiuming ZHANG Xiyang LEI Lei |
| Department of Endocrinology, Aerospace Center Hospital, Beijing 100049, China |
|
|
|
Abstract Objective To observe the relationship of serum thyroid stimulating hormone (TSH) with human chorionic gonadotropin (β-hCG), estrogen and thyroid-associated antibodies in the early pregnancy of pregnant women, and to evaluate the clinical value of TSH screening in early pregnancy. Methods Total 102 healthy pregnant women with 10-12 weeks of perinatal period treated in Aerospace Center Hospital from January to October 2016 were selected as research objects. According to the serum TSH level, they were divided into TSH≤2.5 μU/mL group and TSH＞2.5 μU/mL group. The differences of β-hCG and estrogen between the two groups and the relationship with thyroglobulin antibodies (TGAb) and thyroid peroxidase antibody (TPOAb) were compared. Results There were significant differences in the levels of β-hCG between the two groups (P ＜ 0.05), and the increase of serum TSH had a correlation with thyroid-associated antibodies. Conclusion The increase of TSH levels in early pregnancy is related to β-hCG and thyroid-associated antibodies.
|
|
|
|
|
|
[1] 韩娜，于静，刘晓玲.胎儿生长受限与母血中甲状腺素关系的研究[J].中国优生与遗传杂志，2013，21（3）：75.
[2] Blatt AJ，Nakamoto JM，Kaufman HW. National status of testing for hypothyroidism during pregnancy and postpartum [J]. J Clin Endocrinol Metab，2012，97（3）：777-784.
[3] 陈彦彦，滕卫平，单忠艳，等.妊娠前半期甲状腺功能减退症的临床流行病学调查[J].中华内分泌代谢杂志，2008， 24（6）：597-600.
[4] Sheehan PM，Nankervis A，Araujo Júnior E，et al. Maternal Thyroid Disease and Preterm Birth：Systematic Review and Meta-Analysis [J]. J Clin Endocrinol Metab，2015，100（11）：4325-4331.
[5] Dichtel LE，Alexander EK. Preventing and treating maternal hypothyroidism during pregnancy [J]. Curr Opin Endocrinol Diabetes Obes，2011，18（6）：389-394.
[6] Henrichs J，Bongers-Schokking JJ，Schenk JJ，et al. Maternal thyroid function during early pregnancy and cognitive functioning in early childhood：the generation R Study [J]. J Clin Endocrinol Metab，2010，95（9）：4227-4234.
[7] 蒲杰，刘兴会.妊娠期甲状腺功能减退的研究进展[J].实用妇产科杂志，2014，30（7）：497-501.
[8] 单忠艳.妊娠合并甲状腺功能减退症的进展和争论[J].内科理论与实践，2010，5（2）：125-129.
[9] Stagnaro-Green A，Abalovich M，Alexander E，et al. Guidelines of the American Thyroid Association for the diagnosis and management of thyroid disease during pregnancy and postpartum [J]. Thyroid，2011，21（10）：1081-1125.
[10] Garber JR，Cobin RH，Gharib H，et al. Clinical practice guidelines for hypothyroidism in adults：cosponsored by the American Association of Clinical Endocrinologists and the American Thyroid Association [J]. Endocr Pract，2012，18（6）：988-1028.
[11] 蔺莉.妊娠期甲状腺功能保护[J].中国实用妇科与产科杂志，2012，28（8）：580-583.
[12] 张慧丽，杜培丽，何玉甜，等.关于“妊娠期甲状腺功能亢进症诊治指南”的解读[J].中国实用妇科与产科杂志，2012，28（8）：561-565.
[13] 黄之虎，黄翠波，黄小明.早孕期孕妇促甲状腺激素检测临床意义研究[J].检验医学与临床，2014，11（4）：459-462.
[14] 戴维，江咏梅.妊娠期甲状腺功能筛查指标的参考值建立及方法学研究现状[J].中华检验医学杂志，2013，36（1）：10-13.
[15] 朱丹.妊娠亚临床甲状腺功能减退症合并甲状腺过氧化物酶抗体阳性89例临床分析[J].中外医学研究，2016， 14（17）：26-28.
[16] Alexander E，Marqusee E，Lawrence J，et al. Timing and magnitude of increase in levothyroxine requirements during pregnancy in women with hypothyrioidism [J]. N Engl J Med，2004，351（3）：241-249.
[17] 王小红.亚临床甲状腺功能减退及TPOAb阳性对妊娠结局及胎儿结局的研究[J].中国现代医生，2016，54（15）：34-38.
[18] 李玉姝，单忠艳，关海霞，等.甲状腺过氧化物酶抗体和甲状腺球蛋白抗体阳性临界值的确定及其临床意义[J].中华检验医学杂志，2006，29（9）：780-783.
[19] 宁雪金.抗甲状腺过氧化物酶抗体检测在妊娠早期的应用价值[J].中国医学创新，2016，13（15）：65-68.
[20] 林敏，钱小泉，郑建红，等.亚临床甲状腺功能减退症孕期筛查及意义[J].中国现代医生，2015，53（21）：45-47，50.
[21] Nicholson WK，Robinson KA，Smallridge RC，et al. Prevalence of postpartum thyroid dysfunction：a quantitative review [J]. Thyroid，2006，16（6）：573-582.
[22] 丘文慧，朱月琼，廖奇峰，等.甲状腺激素水平对高龄产妇自身免疫功能和妊娠结局的影响研究[J].中外医学研究，2015，13（1）：63-65.
[23] Negro R，Formoso G，Mangieri T，et al. Levothyroxine treatment in euthyroid pregnant women with autoimmune thyroid disease：effect on obstetrical complication [J]. J Cliln Endocrinol Metab，2009，89（8）：87-91.
[24] 张淼，时立新.2012年中国《妊娠和产后甲状腺疾病诊治指南》解读[J].中国实用内科杂志，2012，32（10）：761-763.
[25] 滕卫平，段涛，宁光，等.妊娠和产后甲状腺疾病诊治指南[J].中华内分泌代谢杂志，2011，28（5）：354-371. |
|
|
|
