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| Research progress on mechanism of comorbidity of epilepsy and Alzheimer disease |
| ZHAO Juan ZHANG Yanmei ZHENG Naizhi |
| Qingdao Municipal Hospital Affiliated to Qingdao University, Shandong Province, Qingdao 266011, China |
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Abstract Epilepsy and Alzheimer disease (AD) are common diseases in neurology, whose pathogenesis is complex and lack of effective treatment. The existing studies have shown that significant correlations are found in the etiology, pathogenesis, pathological changes, clinical, manifestations, treatment and other aspects of these two diseases. In recent years, researches on the two disease are mainly about the inflammation, degeneration and the function abnormalities of the neural network and disease caused by neural immune. In this paper, it reviews the research progress on the pathogenesis of epilepsy and AD from neural degeneration and abnormal network function [including: amyloid beta protein and abnormal excitatory neural network; hippocampal sclerosis in the pathogenesis of EP and AD correlation; EP in AD patients; tau protein dependent voltage-gated potassium channel Kv4.2 (Kv4.2) deletion and dendritic hyperexcitability] and the role of immune inflammatory response in the pathogenesis of EP and AD .
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