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Research progress of microRNA and lncRNA in myocardial fibrosis |
GAO Yuqiu JIAO Lei ZHANG Ying |
Department of Pharmacology, College of Pharmacy, Harbin Medical University Key Laboratory of Cardiovascular Medicine Research, Heilongjiang Province, Harbin 150086, China |
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Abstract Myocardial fibrosis is the process of excessive accumulation of collagen fibers in myocardial tissue. In recent years, the role of non coding RNA including small RNA (miRNA) and long non-coding RNA (lncRNA), has become a hot topic. miRNA and lncRNA regulate the occurrence and development of myocardial fibrosis by activating multiple signaling pathways and mechanisms. This article reviews the mechanism and research progress of miRNA and lncRNA in myocardial fibrosis.
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