纳米银敷料结合抗生素用于慢性伤口感染干预效果的研究

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Abstract Objective To evaluate the effect of nano silver dressing in combination with antibiotics for chronic wound infection treatment, in order to provide the basis for rational use of silver dressing and optimization of wound treatment in clinic. Methods 189 cases of patients with chronic wound infection treated in Wound Outpatient of the Second Hospital of Lanzhou University, People's Hospital Affiliated to Hubei University of Medicine, the First Clinical Medical College of China Three Gorges University from January 2012 to June 2016 were selected. According to multi-center randomized controlled method, patients were divided into group A, B and C, each group had 63 cases. After the operation process unified assessment and debridement, according to the test design requirements, with the doctor's advice, group A was locally used systemic sensitive antibiotic treatment in combination with nano silver dressing process, group B was only partial used nano silver dressing treatment, group C was given intravenous infusion of sensitive antibiotics, and locally used vaseline dressing processing with 30 days intervention. All patients followed up for 30 days, they were treated by overall intervention, such as full nutrition, activity, pain, stress. The pathogens and resistant bacteria positive rates, wound scores and pH value at different time after intervention, healing time and wound healing rate within 60 days were recorded. Results With the longer duration of intervention, except the group C had no significant decreasing of positive rate of resistant bacteria, in other groups the positive rates of pathogenic bacteria and resistant bacteria, and pH values were all decreased, and wound scores increased (P < 0.05). Comparison in the three groups: after the intervention for 14 d and 21 d, the observation indexes of group A were significantly better than group B and group C, in which, group B were better than those of group C, the differences were statistically significant (P < 0.01). The wound healing rate of group A was higher than that of group B and group C, and the healing time was shorter than group B and group C, with statistically significant differences (P < 0.01). Conclusion Antibiotic treatment in combination with nano silver dressing for chronic chronic wound infection has synergistic antibacterial effect, which can optimize the wound microacid environment, promot wound repair, in order to provide the basis for the evidence-based treatment.

Key words： Chronic wound Nano silver dressing Pathogenic bacteria Drug-resistant bacteria Micro environment

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	GUO Chunlan XI Zuyang DAI Delan

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GUO Chunlan XI Zuyang DAI Delan. Research on intervention effect of nano silver dressing in combination with antibiotics for chronic wound infection[J]. 中国医药导报, 2017, 14(28): 60-64.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2017/V14/I28/60

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