|
|
Clinical effect of Phloroglucinol Injection combined with Gushen Antai Pills in treatment of threatened abortion |
HE Wenfeng1 JIANG Yanhua1 TANG Shuqiong2 |
1.Department of Obstetrics and Gynecology, Luohu District Women and Children′s Health Care Hospital of Shenzhen, Guangdong Province, Shenzhen 518019, China;
2.Department of Obstetrics and Gynecology, Luzhou Traditional Chinese Medicine Hospital, Sichuan Province, Luzhou 646000, China |
|
|
Abstract Objective To explore the effect of phloroglucinol injection combined with Gushen Antai Pills in the treatment of threatened abortion. Methods From February 2016 to April 2018, 109 pregnant women with threatened abortion admitted in Luohu District Women and Children′s Health Care Hospital of Shenzhen were selected, and they were divided into control group (54 cases) and study group (55 cases) according to the random number table method. The pregnant women in control group were treated with Phloroglucinol Injection, and the pregnant women in study group were treated with Phloroglucinol Injection combined with Gushen Antai Pills. The clinical efficacy was compared between the two groups, the serum index [human chorionic gonadotropin (β-HCG), estradiol (E2) and progesterone (P)] of the two groups were compared before and after treatment, the adverse reaction of the two groups during treatment was recorded. Results After treatment, the total effective rate of study group was higher than that of the control group (P < 0.05). After treatment, the levels of β-HCG, E2 and P were higher than before treatment (P < 0.05), and these in the study group were higher than those in the control group (P < 0.05). The disappearance time of clinical symptoms and uterine contraction in the study group were shorter than those in the control group (P < 0.05). There was no difference in the incidence of adverse reactions in the two groups during the treatment period (P > 0.05). Conclusion Phloroglucinol Injection combined with Gushen Antai Pills is effective in the treatment of threatened abortion. It can effectively improve the clinical symptoms of patients, improve the level of related serum indexes, and it does not increase the incidence of adverse reactions. It has a certain clinical value.
|
|
|
|
|
[1] Lek SM,Ku CW,Allen JC,et al. Validation of serum progesterone<35 nmol/L as a predictor of miscarriage among women with threatened miscarriage [J]. BMC Pregnancy Childbirth,2017,17(1):78.
[2] 刘小清,胡玉维,钟华琴,等.地屈孕酮治疗先兆流产的临床研究进展[J].中国医院用药评价与分析,2015,15(8):1133-1135.
[3] Turgal M,Aydin E,Ozyuncu O. Effect of micronized progesterone on fetal-placental volume in first-trimester threatened abortion [J]. J Clin Ultrasound,2017,45(1):14-19.
[4] 马丹丽,习元堂,蒋凯林,等.滋肾育胎丸联合孕激素治疗先兆流产的Meta分析和间接比较[J].广州中医药大学学报,2018,35(4):751-757.
[5] 刘竹青,朱立波.地屈孕酮与黄体酮联合绒毛膜促性腺激素对先兆流产的有效性评价[J].中国生化药物杂志,2016,36(7):70-72.
[6] 李婷,李晓霞.固肾安胎丸治疗先兆流产的疗效观察[J].医药前沿,2016,6(6):352-353.
[7] 乐杰.妇产科学[M].7版.北京:人民卫生出版社,2008:84.
[8] 周贝,刘亚琳,唐健元,等.我国中药新药临床研究技术指导原则体系发布概况[J].中国临床药理学杂志,2017, 33(18):1850-1852.
[9] Nijhawan N,McMillan K. Threatened litigation returns abortion access to prince edward island after 34 years [J]. Health Law Can,2016,37(1):2-10.
[10] 苏莉,杜小利,李娜,等.先兆流产病因学研究进展[J].山西中医,2018,34(4):57-59.
[11] Beigi A,Esmailzadeh A,Pirjani R. Comparison of risk of preterm labor between vaginal progesterone and 17-alpha-hydroxy-progesterone caproate in women with threatened abortion:a randomized clinical trial [J]. Int J Fertil Steril,2016,10(2):162-168.
[12] 卢培玲,靳桂香,刘伟,等.间苯三酚联合寿胎丸治疗妊娠12~20周先兆流产效果观察[J].山东医药,2016,56(18):68-69.
[13] 应晓萍.中医辅助治疗早期先兆流产的疗效及预后观察[J].中国妇幼健康研究,2015,26(3):617-618,627.
[14] 戴小萍,戴海青,廖宝珊,等.中医整体化医疗模式及临床路径在胎动不安(先兆流产)中的应用评价[J].世界中医药,2017,12(5):1175-1178.
[15] 韩宁,许雅娟.固肾安胎丸联合低分子肝素干预复发性流产妇女血栓前状态的疗效[J].中成药,2017,39(12):2481-2484.
[16] Fu W,Yao J,Li Q,et al. Efficacy and safety of parecoxib/phloroglucinol combination therapy versus parecoxib monotherapy for acute renal colic:a randomized,double-blind clinical trial [J]. Cell Biochem Biophys,2014,69(1):157-161.
[17] 王文萍,党军.固肾安胎丸联合黄体酮软胶囊治疗早期先兆流产60例[J].陕西中医,2016,37(11):1451-1452.
[18] 田春漫,陈波.固肾安胎丸联用黄体酮对先兆流产患者血清β-HCG,P,E2和CA125水平的影响[J].中国中药杂志,2016,41(2):321-325.
[19] Yal?觭in I,Ta?鬤kin S,Pabu?觭cu EG,et al. The value of placental protein 13,β-human chorionic gonadotropin and progesterone in the prediction of miscarriages in threatened miscarriage patients [J]. J Obstet Gynaecol,2015, 35(3):283-286.
[20] 郑晓霞,舒景,康永茂,等.阴道超声结合CA125、P、E2、β-HCG检测对先兆流产的临床意义[J].长春中医药大学学报,2016,32(2):399-400.
[21] 王文珍,金文婷,满玉晶,等.孕酮、雌二醇、血β-hCG水平与早期妊娠相关性的探讨[J].中外医学研究,2015, 13(32):154-156.
[22] 陈艳萍.血清孕酮及β-hCG检测在诊断早期先兆流产中的临床研究[J].中国医药科学,2017,7(3):116-118, 145.
[23] 冷冬月,陈双郧.固肾安胎丸对肾阴虚型早期先兆流产的疗效及激素水平的影响[J].湖北中医药大学学报,2013, 15(6):55-56. |
|
|
|