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| Predictive value of peripheral blood fetal hemoglobin, placental growth factor and uterine artery pulsation index for re-pregnancy early preeclampsia in patients with early onset preeclampsia history |
| ZHAO Jinheng WANG Qian LI Juan ZHANG Guixin |
| Department of Gynaecology and Obstetrics, Tangshan Maternity and Child Health Care Hospital, Hebei Province, Tangshan 063000, China |
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Abstract Objective To explore the predictive value of combined detection of peripheral blood fetal hemoglobin, placental growth factor, and uterine artery pulse index for re-pregnancy early preeclampsia in patients with early-onset preeclampsia history. Methods From January 2010 to August 2017, in Tangshan Maternity and Child Health Care Hospital, 94 premature pregnancy with preeclampsia history were selected as the subjects. The predictive value of maternal placental growth factor (PLGF), peripheral blood fetal hemoglobin (HbF) and uterine artery pulsatility index (PI) for early onset preeclampsia was observed and analyzed. Results Among 94 pregnant women, 21 cases occurred early onset preeclampsia, the incidence of which was 22.34%. The PLGF level in early onset preeclampsia pregnant women was lower than non early onset preeclampsia pregnant women (P < 0.05), and HbF and PI levels were higher than those in non early onset preeclampsia pregnant women (P < 0.05). The sensitivity of PLGF positive or HbF positive or PI positive in predicting preeclampsia was higher than that of all PLGF, HbF and PI positive (P < 0.05). The specificity of PLGF positive or HbF positive or PI positive in predicting preeclampsia was higher than that of all PLGF, HbF and PI positive (P < 0.05). Conclusion PLGF, HbF and PI are all positive can be taken as prediction criteria to reduce the rate of misdiagnosis, which is beneficial to the diagnosis of early onset preeclampsia. PLGF, HbF or PI positive can be taken as a prediction standard to reduce the missed diagnosis rate, it is beneficial to the elimination of early onset preeclampsia.
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[1] 高漫，刘彤，张岩，等.AP-2α、E-cadherin及β-catenin与早发型子痫前期的相关性[J].中国医科大学学报，2014， 43（6）：527-529.
[2] 蔡仁梅，瓮占平，王云英，等.S100B蛋白表达与早发型及晚发型子痫前期发病的关系[J].中华妇产科科杂志，2012，47（7）：510-513.
[3] 杨丽萍，侯俊德，申自玮，等.sFlt-1及PLGF的表达与早发型子痫前期的相关性[J].实用医学杂志，2014，30（14）：2263-2264.
[4] 吴金儿，茅味蓉，朱宏涛，等.子痫前期病史孕妇再次妊娠临床特点及母婴结局分析[J].中国妇幼健康研究，2017， 28（4）：414-415，477.
[5] 徐艳霞，赵先兰，周艳.低分子肝素对早发型子痫前期患者再次妊娠结局的影响[J].现代妇产科进展，2016，25（12）：937-938，941.
[6] Li XL，Chen TT，Dong X，et al. Early onset preeclampsia in subsequent pregnancies correlates with early onset preeclampsia in first pregnancy [J]. Eur J Obstet Gynecol Reprod Biol，2014，177（22）：94-99.
[7] 张檀，程显.早中孕期有关血清筛查指标与子痫前期的相关性研究[J].浙江预防医学，2015，27（12）：1213-1216.
[8] 姚秀芝.早发型重度子痫前期再次妊娠血压正常时围生儿结局[J].中国实用神经疾病杂志，2011，14（9）：57-59.
[9] 杨萍，何霞.早发型重度子痫前期患者血清高密度脂蛋白和尿酸水平的变化及临床意义[J].中国医药科学，2017，7（14）：59-61.
[10] 张燕飞.子痫前期再次妊娠的临床分析[D].杭州：浙江大学，2015.
[11] 彭兰，戴建荣，柴利强，等.胎盘蛋白13与胎盘生长因子在子痫前期高危人群中的表达及预测意义[J].中国现代医药杂志，2015，17（1）：26-29.
[12] 祁锋，柯冬香，郑灵芝. 胎盘蛋白13联合子宫动脉搏动指数在不同孕周预测子痫前期的研究[J].浙江实用医学，2014，19（3）：171-173.
[13] 梁旭霞，李静，张春，等. 母血清学指标α1微球蛋白、胎儿血红蛋白对于预测子痫前期的临床意义[J].中国妇幼保健，2016，31（3）：497-498.
[14] Anderson UD，Olsson MG，Rutardottir S，et al. Fetal hem-oglobin and α1-microglobulin as first- and early second-trimester predictive biomarkers for preeclampsia [J]. Am J Obstet Gynecol，2011，204（6）：520.e1-5.
[15] 顾颖，冯亚玲，许倩.胎盘蛋白13联合胎盘生长因子早期筛查子痫前期ROC曲线分析[J].中国卫生统计，2017， 34（5）：790-791，794.
[16] 苗晓.早发型子痫前期期待治疗对围生儿结局影响因素分析[J].首都医科大学学报，2015，36（3）：465-468.
[17] 倪琰琰，程蔚蔚.早发型子痫前期的预测研究进展[J].东南大学学报：医学版，2016，35（1）：135-138.
[18] 苏秀梅，李林娜.妊娠晚期血脂水平与不同类型子痫前期相关性分析[J].中山大学学报：医学科学版，2016，37（3）：428-432.
[19] 吴璠，华绍芳，李月琴，等.孕前肥胖的早发型子痫前期患者临床特点与围产结局分析[J].天津医药，2016，44（6）：759-762.
[20] 华绍芳，李月琴.早发子痫前期患者血浆胎盘生长因子水平与围生结局的研究[J].实用妇产科杂志，2017，33（10）：768-771.
[21] Bavare AC，Thomas JK，Gurganious LM，et al. Fostering self-determination of bedside providers to promote active participation in rapid response events [J]. Med Educ Online，2019，24（1）：1551028. |
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