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| The efficacy of the interferon-γ release assay for diagnosing cervical tuberculous lymphadenitis |
| XU Hui1 YAN Guangpeng1 MA Jin2 TANG Hui2 XIA Zhigang2 YU Jing3 LI Jun1 |
1.Department of Oral and Maxillofacial Surgery, People′s Hospital of Xinjiang Uygur Autonomous Region, Xinjiang Uygur Autonomous Region, Urumqi 830001, China;
2.Department of Laboratory, People′s Hospital of Xinjiang Uygur Autonomous Region, Xinjiang Uygur Autonomous Region, Urumqi 830001, China; 3.Department of Pediatrics, People′s Hospital of Xinjiang Uygur Autonomous Region, Xinjiang Uygur Autonomous Region, Urumqi 830001, China |
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Abstract Objective To evaluate the performance of interferon-γ release assay (IGRAs) in patients with suspected cervical tuberculous lymphadenitis. Methods From December 2014 to April 2016, 94 patients with abnormal cervical lymph node in People′s Hospital of Xinjiang Uygur Autonomous Region were categorized into cervical tuberculous lymphadenitis group (52 cases) and nonactive cervical tuberculous lymphadenitis group (42 cases) according to histopathologic and microbiological findings. IGRAs using peripheral blood mononuclear cells was performed to examine the IFN-γ response to the Mycobacterium tuberculosis-specific antigens. The number of cells (SFCs) in two groups was compared. Results SFCs median in cervical tuberculous lymphadenitis group (90) was significantly higher than that in non-cervical tuberculous lymphadenitis group (0), the difference was statistically significant (P ＜ 0.05). The sensitivity of peripheral blood gamma-interferon release assay was 92.31% (48/52), the specificity was 69.05% (29/42), the positive predictive value was 78.69%, the negative predictive value was 87.88%. Conclusion In a high tuberculosis burden setting, results of IGRAs are of limited value in the diagnosis of cervical tuberculous lymphadenitis.
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