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| Advance research on the role of cancer-associated fibroblasts in oral squamous cell carcinoma and its targeted therapy |
| ZHANG Wenwen1 LIU Keke1 LIU Luyao1 CAO Juan1 LI Bo1 DONG Chunling2 |
1.Experimental Teaching Center, School and Hospital of Stomatology, Jilin University, Jilin Province, Changchun 130021, China;
2.Department of Respiratory Medicine, the Second Hospital, Jilin University, Jilin Province, Changchun 130041, China |
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Abstract Oral squamous cell carcinoma (OSCC) is the sixth most common malignant tumor in the world with a five-year survival rate of less than 50%. Its pathogenesis has not been fully elucidated. Cancer-associated fibroblasts (CAFs), as one of the important cellular components in the tumor microenvironment, play an important role in tumor invasion, metastasis and angiogenesis. CAFs promote tumor development mainly by releasing growth factors, modifying extracellular matrix, supporting angiogenesis, and inhibiting anti-tumor immune responses. CAFs-targeted therapy may effectively inhibit the invasion and metastasis of OSCC, and limit tumor angiogenesis, which provides new strategies for the treatment of OSCC. This article comprehensively discusses the advance research on the role of CAFs in OSCC and its targeted therapy.
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