脑脊液酶谱在阿尔茨海默病中的研究进展

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Abstract Alzheimer′s disease (AD) is an age-related and progressive neurodegenerative disease, which is the most common disease leading to dementia. AD develops slowly and becomes severe progressively. In the development of AD, different stages are accompanied with corresponding pathophysiological changes, where the enzymes in the cerebrospinal fluid of patients with AD can be used as biomarkers to reflect the developing process of AD, and before the dementia stage of AD, there is a preclinical stage ranging from years to decades. In this way, it is of great significance to the early diagnosis and treatment of AD. This review focuses on the current research of some enzymes in the cerebrospinal fluid of AD.

Key words： Alzheimer′s disease Cerebrospinal fluid Enzyme BACE1 KLK6 Matrix metalloproteinases

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	ZHANG Qihao1
	2 LIU Chengeng1 WANG Peichang1

Cite this article:

ZHANG Qihao1,2 LIU Chengeng1 WANG Peichang1. Advances of cerebrospinal fluid enzyme spectrum in Alzheimer′s disease[J]. 中国医药导报, 2019, 16(14): 19-22.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I14/19

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