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| Characteristics and clinical application of nalbuphine hydrochloride |
| YU Qiao1 CHEN Chun2 |
1.First Clinical Medicine College, China Three Gorges University, Hubei Province, Yichang 443003, China;
2.Department of Anesthesiology, Yichang Central People's Hospital, Hubei Province, Yichang 443003, China |
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Abstract Nalbuphine Hydrochloride ("Nalbuphine" for short) is a synthetic opioid agonist-antagonist analgesic derivative of the phenanthree group, it can be combined with μ, κ, δ receptor, activating κ receptors, providing central analgesic and sedative effects; partially antagonized the μ opioid receptor, thus reducing the side effects associated with the excitement of opioid receptor, especially onrespiratory depression, nausea, vomiting and pruritus. Nalbuphine is mainly metabolized by liver, clearanced by intestinal, a small part clearanced by the renal. The analgesic effect of nalbuphineis rapid onset , long duration of action. On abroad, it has been used for postoperative analgesia and analgesia in gynecological and pediatric surgery; in the domestic, since the market Nalbuphine has attracted a lot of attention, mainly used for mild to moderate pain caused by various reasons, due to the low rate of adverse reactions, so it has broad application prospects.
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