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| Changes and clinical significance of thrombus elastograms in pregnant women |
| YANG Jianling1 LI Hua1 MA Xingxuan1▲ TANG Shifu1 LIU Shi2 JIAN Jie3 WANG Lei1 ZHANG Liang1 |
1.Department of Laboratory, Liuzhou Traditional Chimese Medicine Hospital, Guangxi Zhuang Autonomous Region, Liuzhou 545001, China;
2.Department of Laboratory, Hu′nan Provincial People′s Hospital, Hu′nan Province, Changsha 410005, China;
3.Department of Obstetrics, Liuzhou Traditional Chimese Medicine Hospital, Guangxi Zhuang Autonomous Region, Liuzhou 545001, China |
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Abstract Objective To explore the changes and clinical significance of thrombus elastograms in pregnant women. Methods From January 2018 to December 2018, 77 pregnant women with gestational age ＜ 36 weeks were selected as the observation group 1, 77 pregnant women with gestational age ≥ 36 weeks as the observation group 2, and 77 healthy women without pregnancy during the same period as the control group. The parameters of TEG of the three groups of women were compared, and the reference value range was established by comparing the different parameters, and the correlation analysis was conducted between the traditional blood coagulation indexes and TEG test results of pregnant women. Results There were statistically significant differences in TEG parameters comparison, pregnant women in the coagulation reaction time (R), clotting time (K), blood clots forming speed (α angle), maximum amplitude (MA), MA determine the rate of 30 min after fibrinolysis (LY30) and synthetic blood clotting index (CI) between observation group 1,2 and control group (P ＜ 0.05). In terms of routine coagulation parameters, there were statistically significance differences between pregnant women and healthy women in prothrombin time (PT) and activated partial thrombin time (ATPP) (P ＜ 0.05). Compared with observation group 1, except LY30, TEG test indexes of observation group 2 were significantly shortened (P ＜ 0.05), there was no significant change in other indexes. In terms of the correlation between TEG and conventional coagulation parameters in pregnant women, except for α angle, the parameter values of other indicators had a certain correlation with traditional coagulation parameters, and PT and MA were positively correlated. APTT was positively correlated with R and negatively correlated with MA and CI. The positive correlation between INR and LY30 was low. Plt was negatively correlated with K value and positively correlated with MA and CI value. TT was positively correlated with MA. Conclusion TEG can dynamically and comprehensively observe the maternal blood coagulation function, and correct the maternal blood coagulation function reasonably and effectively according to the indicators, which has important clinical significance for reducing the surgical risk.
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